DKK3 (Protein | Antibody | cDNA Clone | ELISA Kit)

All DKK3 reagents are produced in house and quality controlled, including 9 DKK3 Antibody, 3 DKK3 ELISA, 15 DKK3 Gene, 1 DKK3 Lysate, 1 DKK3 Protein, 2 DKK3 qPCR. All DKK3 reagents are ready to use.

DKK3 Protein (1)

DKK3 Antibody (9)

DKK3 ELISA Kit & Match Antibody ELISA Pair Set (3)

DKK3 cDNA Clone (15)

NM_001018057.1

In expression vector

NM_015814.2

DKK3 Lysate (1)

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DKK3 Background

DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 protein is proposed to function as a secreted tumor suppressor since it is downregulated in a number of cancer cells and prostate cancer tissue and may be a promising candidate molecule for therapeutic interference. DKK3 protein is also a negative regulator of beta-catenin and its downregulation contribute to an activation of the beta-catenin signaling pathway.

DKK3 References

  • Yue W, et al., 2008. Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer. Carcinogenesis, 29 (1): 84-92.
  • Ding Z, et al., 2009. Promoter methylation and mRNA expression of DKK3 and WIF-1 in hepatocellular carcinoma. World J Gastroenterol, 15 (21):2595-601.