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DKK1/Dkk-1  Protein, Antibody, ELISA Kit, cDNA Clone

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表達宿主: Human Cells  
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10170-H08H-20
10170-H08H-100
10170-H08H-5
20 µg 
100 µg 
5 µg 
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表達宿主: Human Cells  
  • Slide 1
57248-M08H-10
57248-M08H-50
10 µg 
50 µg 
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描述: Active  
表達宿主: Human Cells  
  • Slide 1
11089-K08H-100
11089-K08H-20
11089-K08H-5
100 µg 
20 µg 
5 µg 
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描述: Active  
表達宿主: Human Cells  
  • Slide 1
11089-K05H-5
11089-K05H-100
11089-K05H-20
5 µg 
100 µg 
20 µg 
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DKK1/Dkk-1 相關信號通路

DKK1/Dkk-1 相關蛋白、抗體、cDNA基因、ELISA試劑盒

DKK1/Dkk-1 概述&蛋白信息

DKK1/Dkk-1 研究背景

基因概述: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
General information above from NCBI
亞單位結構: Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling.
結構域: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity).
亞細胞定位: Secreted.
組織特異性: Placenta.
相似的序列: Belongs to the dickkopf family.
General information above from UniProt

Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.

DKK1/Dkk-1 別稱

SK,DKK-1, [homo-sapiens]
S,Dickkopf 1,DKK1,DKK-1,hDKK 1,SK, [human]
mdkk-1, [mus-musculus]

DKK1/Dkk-1 相關文獻

  • Horwitz EM. (2004) Dkk-1-mediated expansion of adult stem cells. Trends Biotechnol. 22(8): 386-8.
  • Jiang T, et al. (2009) Clinical significance of serum DKK-1 in patients with gynecological cancer. Int J Gynecol Cancer. 19(7): 1177-81.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”