快速訂購

留言    收藏

DKK-1 中和抗體

    產品資料評論相關產品實驗方法
     DKK1 抗體產品資訊
    免疫原:Recombinant Human DKK-1 Protein (Catalog#10170-H08H)
    Clone ID:R015
    Ig類型:Rabbit IgG
    濃度:
    內毒素:< 3 EU/mg
    緩衝液:0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
    抗體製備方法:This antibody was obtained from a rabbit immunized with purified, recombinant Human DKK-1 (rh DKK-1; Catalog#10170-H08H; NP_036374.1; Met2-His266) and was produced using recombinant antibody technology.
    Other DKK1 Antibody Products
    Immunochemical staining of human CD40 in human tonsil with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
    DKK1/Dkk-1 研究背景

    Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.

     DKK1/Dkk-1 參考資料
  • Horwitz EM. (2004) Dkk-1-mediated expansion of adult stem cells. Trends Biotechnol. 22(8): 386-8.
  • Jiang T, et al. (2009) Clinical significance of serum DKK-1 in patients with gynecological cancer. Int J Gynecol Cancer. 19(7): 1177-81.
  • Product nameProduct name
    Size / Price
    貨號: 10170-R015-500
    目錄價: 
    單價:      (You Save: )

    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”