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CD209/DC-SIGN  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
10200-H01H-50
10200-H01H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
90319-C01H-50
90319-C01H-200
50 µg 
200 µg 
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表達宿主: Human Cells  
90319-C07H-50
90319-C07H-200
50 µg 
200 µg 
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CD209/DC-SIGN 相关研究领域

CD209/DC-SIGN 相關信號通路

    CD209/DC-SIGN 概述&蛋白信息

    CD209/DC-SIGN 研究背景

    基因概述: This CD209 gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. DC-SIGN is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. DC-SIGN is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This CD209 gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
    General information above from NCBI
    亞單位結構: Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus envelope glycoproteins, cytomegalovirus gB, HCV E2 and dengue virus major envelope protein E. Interacts with C1QBP; the interaction is indicative for a C1q:C1QBP:CD209 signaling complex. {ECO:0000269|PubMed:10721995, ECO:0000269|PubMed:11017109, ECO:0000269|PubMed:11384997, ECO:0000269|PubMed:11739956, ECO:0000269|PubMed:11799126, ECO:0000269|PubMed:12433371, ECO:0000269|PubMed:12502850, ECO:0000269|PubMed:1518869, ECO:0000269|PubMed:15371595, ECO:0000269|PubMed:22700724}.
    結構域: The tandem repeat domain, also called neck domain, mediates oligomerization.
    亞細胞定位: Isoform 1: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; Isoform 2: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; Isoform 3: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; Isoform 4: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; Isoform 5: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; Isoform 6: Secreted {ECO:0000305}.; Isoform 7: Secreted {ECO:0000305}.; Isoform 8: Secreted {ECO:0000305}.; Isoform 9: Secreted {ECO:0000305}.; Isoform 10: Secreted {ECO:0000305}.; Isoform 11: Secreted {ECO:0000305}.; Isoform 12: Secreted {ECO:0000305}.
    組織特異性: Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes. {ECO:0000269|PubMed:11257134, ECO:0000269|PubMed:11337487}.
    相似的序列: Contains 1 C-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00040}.
    General information above from UniProt

    Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    CD209/DC-SIGN 別稱

    CD209/DC-SIGN 相關文獻

  • Geijtenbeek TB, et al. (2002) DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J Leukoc Biol. 71(6): 921-31.
  • Masso M. (2003) DC-SIGN points the way to a novel mechanism for HIV-1 transmission. MedGenMed. 5(2): 2.
  • Zhou T, et al. (2006) DC-SIGN and immunoregulation. Cell Mol Immunol. 3(4): 279-83.
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