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Cyclophilin A  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: E. coli  
10436-H08E-200
10436-H08E-100
200 µg 
100 µg 
Add to Cart
  • Slide 1
表達宿主: E. coli  
50296-M08E-200
50296-M08E-100
200 µg 
100 µg 
Add to Cart
  • Slide 1

Cyclophilin A 相关研究领域

Cyclophilin A 相關信號通路

    Cyclophilin A 概述&蛋白信息

    Cyclophilin A 研究背景

    基因概述: PPIA gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    催化活性: Peptidylproline (omega=180) = peptidylproline (omega=0).
    酶調控: ENZYME REGULATION: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
    亞單位結構: Interacts with HIV-1 Capsid protein. {ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:20364129, ECO:0000269|PubMed:8513493}.
    亞細胞定位: Cytoplasm {ECO:0000269|PubMed:16527992}. Secreted {ECO:0000269|PubMed:16527992}. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
    翻譯後修飾: Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition. {ECO:0000269|PubMed:20364129, ECO:0000269|Ref.12}.
    相似的序列: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. {ECO:0000305}.; Contains 1 PPIase cyclophilin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00156}.
    General information above from UniProt

    Peptidyl-prolyl cis-trans isomerase A, also known as PPIase A, Rotamase A, Cyclophilin A, Cyclosporin A-binding protein, PPIA and CYPA, is a cytoplasm protein which belongs to the cyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins (CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity, suggesting that they influence the conformation of proteins in cells. PPIA / Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIA / Cyclophilin A is secreted by vascular smooth muscle cells in response to inflammatory stimuli, and could thus contribute to atherosclerosis. It is not essential for mammalian cell viability. PPIA / Cyclophilin A can interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions.

    Cyclophilin A 別稱

    Cyclophilin A 相關文獻

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