All Factor H reagents are produced in house and quality controlled, including 10 Factor H Antibody, 1 Factor H ELISA, 41 Factor H Gene, 3 Factor H Lysate, 3 Factor H Protein, 2 Factor H qPCR. All Factor H reagents are ready to use.
Recombinant Factor H proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
Factor Hantibodies are validated with different applications, which are ELISA, ELISA(Cap), IHC-P, ELISA(Det).
Factor HcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Factor H of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Factor HELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. CFH protects self cells from complement activation but not bacteria/viruses. Due to the central role that CFH plays in the regulation of complement, there are many clinical implications arrising from aberrant CFH activity. Mutations in the Factor H gene are associated with severe and diverse diseases including the rare renal disorders hemolytic uremic syndrome (HUS) and membranoproliferative glomerulonephritis (MPGN) also termed dense deposit disease (DDD), membranoproliferative glomuleronephritis type II or dense deposit disease, as well as the more frequent retinal disease age related macular degeneration (AMD). In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin.