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Cathepsin L/CTSL1  Protein, Antibody, ELISA Kit, cDNA Clone

描述: Active  
表達宿主: Human Cells  
  • Slide 1
10486-H08H-20
10486-H08H-10
20 µg 
10 µg 
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表達宿主: Human Cells  
  • Slide 1
50015-M08H-20
50015-M08H-10
20 µg 
10 µg 
Add to Cart

Cathepsin L/CTSL1 相关研究领域

Cathepsin L/CTSL1 相關信號通路

    Cathepsin L/CTSL1 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    Cathepsin L/CTSL1 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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    Cathepsin L/CTSL1 概述&蛋白信息

    Cathepsin L/CTSL1 研究背景

    基因概述: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.
    General information above from NCBI
    相似的序列: Belongs to the peptidase C1 family. {ECO:0000256|RuleBase:RU004043}.
    General information above from UniProt

    Cathepsin L is a lysosomal cysteine protease that plays a major role in intracellular protein catabolism, and is potent in degrading collagen, laminin, elastin, as well as alpha-1 protease inhibitor and other structural proteins of basement membranes. It is secreted by liver flukes at all stages of their development in the mammalian host, are believed to play important roles in facilitating parasite migration (tissue degradation), feeding and immuno-evasion. Like many proteases, Cathepsin L is synthesized as an inactive preproenzyme, and cleavage of the 96-residue proregion is necessary to generate the fully active 221-residue mature enzyme. Studies have demonstrated that cleavage of the proregion occur autocatalytically under acidic conditions. The enzyme takes part in nutrient acquisition by catabolizing host proteins to absorbable peptides, facilitates the migration of the parasite through the host intestine and liver by cleaving interstitial matrix proteins such as fibronectin, laminin and native collagen and is implicated in the inactivation of host immune defenses by cleaving immunoglobulins. Recently, Cathepsin L has been shown to suppress Th1 immune response in infected laboratory animals making them susceptible to concurrent bacterial infections. Cathepsin L is synthesized in large amounts and secreted by many malignantly transformed cells, and induced by growth factors and tumor promoters. In addition to its role in protein degradation, evidence has accumulated for the participation of Cathepsin L in various physiological and pathological processes, such as tumor invasion and metastasis, bone resorption, spermatogenesis, and arthritis. Accordingly, Cathepsin L may prove useful as a diagnostic or prognostic marker of human tumor malignancy.

    Cathepsin L/CTSL1 別稱

    MEP,CATL,CTSL1, [homo-sapiens]
    Cathepsin L,Cathepsin L1,CATL,CTSL,CTSL1,FLJ31037,MEP, [human]
    1190035F06Rik,Cathepsin L,Cathepsin L1,Ctsl,Ctsl1,fs,nkt,Mep, [mouse]
    fs,MEP,nkt,Ctsl1,1190035F06Rik, [mus-musculus]

    Cathepsin L/CTSL1 相關文獻

  • Mulcahy G, et al. (2001) Cathepsin L proteinases as vaccines against infection with Fasciola hepatica (liver fluke) in ruminants. Res Vet Sci. 70(1): 83-6.
  • Dixit AK, et al. (2008) Immunodiagnostic/protective role of cathepsin L cysteine proteinases secreted by Fasciola species. Vet Parasitol. 154(3-4): 177-84.
  • Leto G, et al. (2010) Cathepsin L in metastatic bone disease: therapeutic implications. Biol Chem. 391(6): 655-64.
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