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Caspase-14 / CASP14 抗體, 兔單抗

  • Caspase-14 / CASP14 Antibody, Rabbit MAb, Immunohistochemistry
產品資料評論相關產品實驗方法
 CASP14 抗體產品資訊
免疫原:Recombinant Human Caspase-14 / CASP14 protein (Catalog#11856-H07E)
Clone ID:001
Ig類型:Rabbit IgG
濃度:
內毒素:
緩衝液:0.2 μm filtered solution in PBS with 5% trehalose
抗體製備方法:This antibody was obtained from a rabbit immunized with purified, recombinant Human Caspase-14 / CASP14 (rh Caspase-14 / CASP14; Catalog#11856-H07E; NP_036246.1; Ser2-Gln242).
 CASP14 Antibody IHC Application Image
Caspase-14 / CASP14 Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of human CASP14 in human skin with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Other CASP14 Antibody Products
Caspase-14/CASP14 研究背景

Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Caspase 14 was not processed by multiple death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapaptotic members of the bcl-2 family. Caspase 14 has been described to be processed and activated by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may take part in keratinocyte terminal differentiation, which is essential for the skin barrier.

 Caspase-14/CASP14 參考資料
  • Hu SM, et al. (1998) Caspase-14 is a novel developmentally regulated protease. The journal of biological chemistry. 273: 29648-53.
  • Marc Van De Craen, et al. (1998) Identification of a new caspase homologue: caspase-14. Cell death differ. 5(10): 838-46.
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    貨號: 11856-R001-50
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    Datasheet & Documentation

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