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CaM Kinase 4/CaMKIV  蛋白

All CAMK4 Reagents

表達宿主: Baculovirus-Insect Cells  
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10664-H09B-20
10664-H09B-50
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50 µg 
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表達宿主: Baculovirus-Insect Cells  
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50838-M20B-20
50838-M20B-50
20 µg 
50 µg 
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表達宿主: Baculovirus-Insect Cells  
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50838-MNCB-20
50838-MNCB-50
20 µg 
50 µg 
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CaM Kinase 4/CaMKIV 相關信號通路

CaM Kinase 4/CaMKIV 相關蛋白、抗體、cDNA基因、ELISA試劑盒

CaM Kinase 4/CaMKIV 概述&蛋白信息

CaM Kinase 4/CaMKIV 研究背景

基因概述: The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.
General information above from NCBI
催化活性: ATP + a protein = ADP + a phosphoprotein.
酶調控: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-200 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-200 results in a 10-20-fold increase in total activity to generate Ca(2+)/calmodulin-independent activity. Autophosphorylation of the N-terminus Ser-12 and Ser-13 is required for full activation. Inactivated by protein phosphatase 2A (PPP2CA/PPP2CB) which dephosphorylates Thr-200, thereby terminating autonomous activity and helping to maintain the enzyme in its autoinhibited state.
亞單位結構: Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is mutually exclusive with binding to Ca(2+)/calmodulin.
結構域: The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
亞細胞定位: Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity).
組織特異性: Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
發育階段: Expressed during differentiation of monocyte- derived dendritic cells (at protein level).
翻譯後修飾: Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13.
Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation.
相似的序列: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Contains 1 protein kinase domain.
General information above from UniProt

Ca2+/ calmodulin-dependent protein kinase 4 (CAMKⅣ) belongs to the serine/threonine protein kinase family, and to the Ca2+/calmodulin-dependent protein kinase subfamily which is widely recognized as an essential enzyme implicated in the phophoinositide amplification cascade. Ca2+/calmodulin dependent protein kinase (CAMK) can be activated by the introcellular increased Ca2+ and then apt to combine with the target protein. Ca2+/ calmodulin-dependent protein kinase 4 (CAMKⅣ) is a multifunctional CaM-dependent kinase protein with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. All of the isforms of this family, including myosin light chain kinase, phosphorylase kinase, CaMK1, CaMKⅢ and CaMKⅣ have EF-hand structure.

CaM Kinase 4/CaMKIV 別稱

CAMK,IV,CaMKIV,CaMK-GR, [homo-sapiens]
caMK,CaMK IV,CaMK-GR,CAMK4,IV,MGC36771, [human]
A430110E23Rik,Camk4,CaMKIV,CaMKIV/Gr,AI666733,caMK IV,D18Bwg0362e, [mouse]
CaMKIV,AI666733,CaMKIV/Gr,D18Bwg0362e,A430110E23Rik, [mus-musculus]

CaM Kinase 4/CaMKIV 相關文獻

  • Feliciano DM, et al. (2009) Repression of Ca2+/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells. J Biol Chem. 284 (39): 26466-81.
  • Zhao X, et al. (2001). The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking. J Biol Chem. 276 (37): 35042-8.
  • Racioppi L, et al. (2008) Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller.
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