快速訂購

NY-ESO-1  Protein, Antibody, ELISA Kit, cDNA Clone

NY-ESO-1 相关研究领域

NY-ESO-1 相關信號通路

    NY-ESO-1 概述&蛋白信息

    NY-ESO-1 研究背景

    亞細胞定位: Cytoplasm {ECO:0000269|PubMed:12065688}.
    組織特異性: Expressed in testis and ovary and in a wide variety of cancers. Detected in uterine myometrium. Expressed from 18 weeks until birth in human fetal testis. In the adult testis, is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells (at protein level). {ECO:0000269|PubMed:12065688}.
    相似的序列: Belongs to the CTAG/PCC1 family. {ECO:0000305}.
    General information above from UniProt

    NY-ESO-1 is another well-characterized CT antigen that appears to be the most immunogenic CT antigen known to date. Integrated humoral and cellular immune response against NY-ESO-1 are frequently observed in patients with tumors with NY-ESO-1 expression. As a member of CT antigens, NY-ESO-1 is expressed in a variety of malignant neoplasms, including melanomas, and esophageal, breast, prostate, urinary tract, ovarian, and lung cancers. Recently, immunohistochemical and molecular analytical approaches for the detection of NY-ESO-1 expression were compared, defining the reliability of each method. However, its clinical significance, e.g. in prognosis, in lung cancer is unclear.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    NY-ESO-1 別稱

    NY-ESO-1 相關文獻

  • Yoshida N, Abe H, Ohkuri T, et al. Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance[J]. International journal of oncology, 2006, 28(5): 1089-1098.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”