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CDK8  Protein, Antibody, ELISA Kit, cDNA Clone

CDK8 相关研究领域

CDK8 相關信號通路

CDK8 概述&蛋白信息

CDK8 研究背景

催化活性: ATP + a protein = ADP + a phosphoprotein. {ECO:0000269|PubMed:10993082}.; ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. {ECO:0000269|PubMed:10993082}.
輔因數: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
亞單位結構: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1. {ECO:0000269|PubMed:10024883, ECO:0000269|PubMed:15175163, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:17000779, ECO:0000269|PubMed:21806996, ECO:0000269|PubMed:9734358}.
亞細胞定位: Nucleus {ECO:0000305}.
相似的序列: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

CDK8 別稱

K35, [homo-sapiens]

CDK8 相關文獻

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