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CDC37  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Baculovirus-Insect Cells  
10647-H09B-50
10647-H09B-20
50 µg 
20 µg 
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表達宿主: Baculovirus-Insect Cells  
50826-MNCB-20
50826-MNCB-100
20 µg 
100 µg 
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表達宿主: Baculovirus-Insect Cells  
50826-M20B-20
50826-M20B-100
20 µg 
100 µg 
Add to Cart
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CDC37 相关研究领域

CDC37 相關信號通路

    CDC37 概述&蛋白信息

    CDC37 研究背景

    基因概述: The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.
    General information above from NCBI
    亞單位結構: Forms a complex with Hsp90/HSP90AB1 and CDK6. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1. {ECO:0000269|PubMed:11036079, ECO:0000269|PubMed:11085988, ECO:0000269|PubMed:9150368, ECO:0000269|PubMed:9482106}.
    亞細胞定位: Cytoplasm {ECO:0000269|PubMed:9482106}.
    翻譯後修飾: Constitutively sumoylated by UBE2I. {ECO:0000269|PubMed:17709345}.
    相似的序列: Belongs to the CDC37 family. {ECO:0000305}.
    General information above from UniProt

    CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is though to play an important role in the establishment of signaling pathways controlling cell proliferation through targeting intrinsically unstable oncoprotein kinases such as Cdk-4, Raf-1, and src to the molecular chaperone Hsp90. Decreased Hsp90 expression can reduce the levels of microtubule-associated protein tau, whose overexpression may induce many diseases. CDC37 is considered as a co-chaperone that is classified to Hsp90's accessory proteins. It has been reported that suppression of Cdc37 destabilized tau, leading to its clearance, whereas cdc37 overexpression preserved tau.Cdc37 was found to co-localize with tau in neuronal cells and to physically interact with tau from human brain. Moreover, Cdc37 levels significantly increased with age.

    CDC37 別稱

    P50CDC37, [homo-sapiens]
    CDC37,P50CDC37, [human]
    Cdc37,p50,p50Cdc37, [mouse]
    p50,p50Cdc37, [mus-musculus]

    CDC37 相關文獻

  • Dai K, et al. (1996) P hysical Interaction of Mammalian CDC37 with CDK4. The journal of biological chemistry. 271: 22030-4.
  • Pearl LH, et al. (2005) Hsp90 and Cdc37-a chaperone cancer conspiracy. Current opinion in genetics development. 15 (1): 55-61.
  • Chen GQ, et al. (2002) TNF-Induced Recruitment and Activation of the IKK Complex Require Cdc37 and Hsp90. Molecular cell. 9 (2): 401-10.
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