快速訂購

CD81/TAPA1  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
14244-H07H-20
14244-H07H-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
14244-H04H-50
14244-H04H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
14244-HNCH-50
14244-HNCH-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
50743-M04H-20
50743-M04H-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
80331-R04H-20
80331-R04H-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
80331-RNCH-20
80331-RNCH-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
90201-C07H-20
90201-C07H-100
20 µg 
100 µg 
Add to Cart
  • Slide 1

CD81/TAPA1 相关研究领域

CD81/TAPA1 相關信號通路

    CD81/TAPA1 概述&蛋白信息

    CD81/TAPA1 研究背景

    亞單位結構: Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. Interacts directly with IGSF8. Interacts with CD53 and SCIMP. Interacts with IFITM1, IFITM2 and IFITM3. Part of a GPCR-tetraspanin complex consisting at least of GPR56, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of GPR56 with GNA11. {ECO:0000269|PubMed:11504738, ECO:0000269|PubMed:12913001, ECO:0000269|PubMed:12970454, ECO:0000269|PubMed:15004227, ECO:0000269|PubMed:21930792, ECO:0000269|PubMed:2398277}.
    亞細胞定位: Membrane; Multi-pass membrane protein.
    組織特異性: Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.
    翻譯後修飾: Not glycosylated. {ECO:0000305}.
    相關疾病 : DISEASE: Immunodeficiency, common variable, 6 (CVID6) [MIM:613496]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269|PubMed:20237408}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    相似的序列: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
    General information above from UniProt

    CD81, also known as TAPA-1, belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Members of this family mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.CD81 is a widely expressed cell-surface protein involved in an astonishing variety of biologic responses. It is related to adhesion, morphology, activation, proliferation, and differentiation of B, T, and other cells. On B cells CD81 is part of a complex with CD21, CD19, and Leu13. This complex reduces the threshold for B cell activation via the B cell receptor by bridging Ag specific recognition and CD21-mediated complement recognition.

    CD81/TAPA1 別稱

    S5.7,CVID6,TAPA1,TSPAN28, [homo-sapiens]
    CD81 molecule,CD81,CVID6,S5.7,TAPA1,TSPAN28,26 kDa cell surface protein TAPA-1,CD81 antigen,CD81 antigen (target of antiproliferative antibody 1),tetraspanin-28,tspan-28, [human]
    CD81 antigen,Cd81,Tapa-1,Tapa1,Tspan28,26 kDa cell surface protein TAPA-1,target of the antiproliferative antibody 1, [mouse]
    Tapa1,Tapa-1,Tspan28, [mus-musculus]

    CD81/TAPA1 相關文獻

  • Petracca R. et al., 2000, J Virol. 74 (10): 4824-30.
  • Bartosch B. et al., 2003, The Journal of Biological Chemistry. 278 (43): 41624-30.
  • Clark KL. et al., 2001, Journal of Immunology. 167 (9): 5115-21.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”