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CD70/CD27L/TNFSF7  Protein, Antibody, ELISA Kit, cDNA Clone

描述: Active  
表達宿主: Human Cells  
10780-H01H-50
10780-H01H-5
10780-H01H-100
50 µg 
5 µg 
100 µg 
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表達宿主: Human Cells  
51129-M04H-50
51129-M04H-200
50 µg 
200 µg 
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表達宿主: Human Cells  
80161-R01H-50
80161-R01H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
80161-R07H-50
80161-R07H-20
50 µg 
20 µg 
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CD70/CD27L/TNFSF7 相关研究领域

CD70/CD27L/TNFSF7 相關蛋白、抗體、cDNA基因、ELISA試劑盒

CD70/CD27L/TNFSF7 概述&蛋白信息

CD70/CD27L/TNFSF7 研究背景

基因概述: The protein encoded by CD70 gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
General information above from NCBI
亞單位結構: Homotrimer. {ECO:0000305}.
亞細胞定位: Membrane; Single-pass type II membrane protein.
相似的序列: Belongs to the tumor necrosis factor family. {ECO:0000305}.
General information above from UniProt

CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates.

Immune Checkpoint
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

CD70/CD27L/TNFSF7 別稱

CD27LG,Cd27l,Tnfsf7, []
CD27L,CD27LG,TNFSF7, [homo-sapiens]
CD27L,CD27LG,CD70,TNFSF7, [human]
Cd27l,CD27LG,Tnfsf7, [mus-musculus]

CD70/CD27L/TNFSF7 相關文獻

  • Adam PJ, et al. (2006) CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. Br J Cancer. 95(3): 298-306.
  • Keller AM, et al. (2007) Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules. Proc Natl Acad Sci U S A. 104(14): 5989-94.
  • Grewal IS. (2008) CD70 as a therapeutic target in human malignancies. Expert Opin Ther Targets. 12(3): 341-51.
  • Boursalian TE, et al. (2009) Targeting CD70 for human therapeutic use. Adv Exp Med Biol. 647: 108-19.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”