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CD62L/L-Selectin  蛋白

All CD62L Reagents

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11838-H08H-200
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50045-M03H-200
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50045-M08H-200
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90168-C08H-200
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表達宿主: Human Cells  
90168-C02H-200
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表達宿主: Human Cells  
90169-C08H-200
90169-C08H-100
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100 µg 
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CD62L/L-Selectin 相关研究领域

CD62L/L-Selectin 相關信號通路

    CD62L/L-Selectin 概述&蛋白信息

    CD62L/L-Selectin 研究背景

    基因概述: This SELL gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. CD62L contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The SELL gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this SELL gene.
    General information above from NCBI
    亞單位結構: Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding.
    亞細胞定位: Membrane; Single-pass type I membrane protein.
    組織特異性: Expressed in B-cell lines and T-lymphocytes. {ECO:0000269|PubMed:2473156}.
    相似的序列: Belongs to the selectin/LECAM family. {ECO:0000305}.; Contains 1 C-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00040}.; Contains 1 EGF-like domain. {ECO:0000255|PROSITE-ProRule:PRU00076}.; Contains 2 Sushi (CCP/SCR) domains. {ECO:0000255|PROSITE-ProRule:PRU00302}.
    General information above from UniProt

    L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.

    CD62L/L-Selectin 別稱

    CD62L/L-Selectin 相關文獻

  • Smalley DM, et al. (2005) L-selectin: mechanisms and physiological significance of ectodomain cleavage. J Cell Mol Med. 9(2): 255-66.
  • Grailer JJ, et al. (2009) L-selectin: role in regulating homeostasis and cutaneous inflammation. J Dermatol Sci. 56(3): 141-7.
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