All CD50 reagents are produced in house and quality controlled, including 11 CD50 Antibody, 1 CD50 ELISA, 13 CD50 Gene, 1 CD50 IPKit, 2 CD50 Lysate, 2 CD50 Protein, 1 CD50 qPCR. All CD50 reagents are ready to use.
Recombinant CD50 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc & His, C-His.
CD50antibodies are validated with different applications, which are FCM, ELISA, IHC-P, ELISA(Cap), WB, IP.
CD50cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD50 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CD50ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
The protein ICAM-3, also known as CD50, is a member of the intercellular adhesion molecule (ICAM) family consisting three members. It is a DC-SIGN ligand that is constitutively expressed on resting leukocytes, and is thus an important molecule for the first immune response. ICAM-3 comprises of five immunoglobulin-like domains, and binds LFA-1 through its two N-terminal domains. It functions not only as an adhesion molecule, but also as a potent signalling molecule. ICAM-3 binds to LFA-1 on antigen-presenting cells (APC) stabilizing the T cell-APC interaction, facilitating signaling through the CD3/TCR complex. However, recent evidence using cultured and transformed T cells suggests ICAM-3 may also function in signaling. It has been reported that CD50 molecule can play a role in developing functionally mature T lymphocytes and its expression increases during the maturation process of T lymphocytes. In addition, the interactions of ICAM-3 and LFA-1 facilitate HIV-1- induced virological synapse formation between T cells. ICAM-3 is associated with an increase of cellular radio-resistance and cancer cell proliferation. It could be considered as a candidate for anti-cancer drug development and as a cancer diagnostic marker.