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CD47  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
  • Slide 1
12283-HCCH-50
12283-HCCH-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
12283-H02H-50
12283-H02H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
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  • Slide 1
57231-M08H-50
57231-M08H-200
50 µg 
200 µg 
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表達宿主: Human Cells  
  • Slide 1
80305-R08H-50
80305-R08H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
80305-R02H-50
80305-R02H-100
50 µg 
100 µg 
Add to Cart

CD47 相关研究领域

CD47 相關信號通路

    CD47 概述&蛋白信息

    CD47 研究背景

    基因概述: CD47 gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. CD47 gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for CD47 gene. [provided by RefSeq, Jul 2010]
    General information above from NCBI
    亞單位結構: Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2. {ECO:0000250, ECO:0000269|PubMed:10549293, ECO:0000269|PubMed:11509594, ECO:0000269|PubMed:15383453, ECO:0000269|PubMed:18657508}.
    亞細胞定位: Cell membrane {ECO:0000269|PubMed:7691831}; Multi-pass membrane protein {ECO:0000269|PubMed:7691831}.
    組織特異性: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.
    相似的序列: Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus.

    Immune Checkpoint
    Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: WB Antibodies
    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    CD47 別稱

    IAP,OA3,MER6, [homo-sapiens]
    antigen identified by monoclonal antibody 1D8,antigenic surface determinant protein OA3,CD47 antigen (Rh-related antigen,CD47 glycoprotein,IAP,integrin associated protein,integrin-associated signal transducer,integrin-associated signal transducer),leukocyte surface antigen CD47,MER6,OA3,Rh-related antigen, [human]
    9130415E20Rik,AA407862,AI848868,AW108519,B430305P08Rik,IAP,integrin-associated protein,Itgp,leukocyte surface antigen CD47,Rh-related antigen, [mouse]
    IAP,Itgp,AA407862,AI848868,AW108519,9130415E20Rik,B430305P08Rik, [mus-musculus]

    CD47 相關文獻

  • Brown EJ, et al. (2001) Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 11(3): 130-5.
  • Oldenborg PA. (2004) Role of CD47 in erythroid cells and in autoimmunity. Leuk Lymphoma. 45(7): 1319-27.
  • Kaczorowski DJ, et al. (2007) Targeting CD47: NO limit on therapeutic potential. Circ Res. 100(5): 602-3.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”