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反應性: Human  
應用 : ELISA  WB  
10400-RP02-50
10400-RP02-200
10400-RP02-100
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200 µg 
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  • Slide 1
反應性: Human  
應用 : ELISA  WB  
10400-R104-50
10400-R104-100
50 µg 
100 µg 
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  • Slide 1
反應性: Human  
應用 : ELISA  
10400-MM03-50
10400-MM03-200
10400-MM03-100
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    反應性: Human  
    應用 : ELISA  
    10400-RP01-400
    10400-RP01-200
    10400-RP01-100
    400 µg 
    200 µg 
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      反應性: Human  
      應用 : WB  
      10400-MM04-50
      10400-MM04-200
      10400-MM04-100
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      200 µg 
      100 µg 
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      • Slide 1
      反應性: Human  
      應用 : FCM  
      10400-MM08-P-25
      10400-MM08-P-100
      25 Test 
      100 Tests 
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      • Slide 1
      • Slide 1
      反應性: Human  
      應用 : ELISA  IHC-P  
      10400-R113-50
      10400-R113-100
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      100 µg 
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      • Slide 1
      • Slide 1
      反應性: Human  
      應用 : FCM  
      10400-MM08-F-25
      10400-MM08-F-100
      25 Test 
      100 Tests 
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      • Slide 1
      • Slide 1
      反應性: Human  
      應用 : FCM  
      10400-MM08-A-25
      10400-MM08-A-100
      25 Test 
      100 Tests 
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      • Slide 1
      • Slide 1
      反應性: Human  
      應用 : FCM  
      10400-MM08-C-25
      10400-MM08-C-100
      25 Test 
      100 Tests 
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      • Slide 1
      反應性: Human  
      應用 : FCM  
      10400-MM08-50
      10400-MM08-200
      10400-MM08-100
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      200 µg 
      100 µg 
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      • Slide 1
      反應性: Human  
      應用 : IHC-P  
      10400-MM22-50
      10400-MM22-200
      10400-MM22-100
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      • Slide 1
      • Slide 1
      • Slide 1
      反應性: Human  
      應用 : ELISA  
      10400-MM07-50
      10400-MM07-200
      10400-MM07-100
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      200 µg 
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        反應性: Mouse  
        應用 : ELISA  IHC-P  
        50134-R001-50
        50134-R001-100
        50 µg 
        100 µg 
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        • Slide 1
        反應性: Mouse  
        應用 : ELISA  
        50134-RP01-400
        50134-RP01-200
        50134-RP01-100
        400 µg 
        200 µg 
        100 µg 
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          反應性: Mouse  
          應用 : ELISA  
          50134-T16-50
          50134-T16-200
          50134-T16-100
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          200 µg 
          100 µg 
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            反應性: Ferret  
            應用 : ELISA  
            60003-MM09-50
            60003-MM09-200
            60003-MM09-100
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            200 µg 
            100 µg 
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              反應性: Ferret  
              應用 : ELISA  
              60003-R108-50
              60003-R108-100
              50 µg 
              100 µg 
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                反應性: Ferret  
                應用 : FCM  
                60003-MM02-A-25
                60003-MM02-A-100
                25 Test 
                100 Tests 
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                • Slide 1
                • Slide 1
                反應性: Ferret  
                應用 : FCM  
                60003-MM02-F-25
                60003-MM02-F-100
                25 Test 
                100 Tests 
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                • Slide 1
                • Slide 1
                反應性: Ferret  
                應用 : 
                60003-MM08-50
                60003-MM08-200
                60003-MM08-100
                60003-MM08-1
                50 µg 
                200 µg 
                100 µg 
                1 mg 
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                  反應性: Ferret  
                  應用 : FCM  
                  60003-MM02-50
                  60003-MM02-100
                  60003-MM02-1
                  50 µg 
                  100 µg 
                  1 mg 
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                  • Slide 1
                  反應性: Ferret  
                  應用 : FCM  
                  60003-MM02-C-25
                  60003-MM02-C-100
                  25 Test 
                  100 Tests 
                  Add to Cart
                  • Slide 1
                  反應性: Ferret  
                  應用 : FCM  
                  60003-MM02-P-25
                  60003-MM02-P-100
                  25 Test 
                  100 Tests 
                  Add to Cart
                  • Slide 1
                  • Slide 1
                  反應性: Ferret  
                  應用 : ELISA  
                  60003-RP02-50
                  60003-RP02-200
                  60003-RP02-100
                  50 µg 
                  200 µg 
                  100 µg 
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                    CD4 相关研究领域

                    CD4 相關信號通路

                    CD4 概述&蛋白信息

                    CD4 研究背景

                    基因概述: CD4 gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This CD4 gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. CD4 functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this CD4 gene.
                    General information above from NCBI
                    亞單位結構: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120. {ECO:0000269|PubMed:11113139, ECO:0000269|PubMed:16331979, ECO:0000269|PubMed:18078954, ECO:0000269|PubMed:2214026, ECO:0000269|PubMed:7909607, ECO:0000269|PubMed:9641677}.
                    亞細胞定位: Cell membrane {ECO:0000269|PubMed:12517957}; Single-pass type I membrane protein {ECO:0000269|PubMed:12517957}. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
                    翻譯後修飾: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. {ECO:0000269|PubMed:1618861}.
                    相似的序列: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
                    General information above from UniProt

                    T-cell surface glycoprotein CD4,  is a single-pass type I membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. The CD4 surface determinant, previously associated as a phenotypic marker for helper/inducer subsets of T lymphocytes, has now been critically identified as the binding/entry protein for human immunodeficiency viruses (HIV). The human CD4 molecule is readily detectable on monocytes, T lymphocytes, and brain tissues. All human tissue sources of CD4 bind radiolabeled gp120 to the same relative degree; however, the murine homologous protein, L3T4, does not bind the HIV envelope protein. CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR. CD4 interacts directly with MHC class II molecules on the surface of the antigen presenting cell via its extracellular domain. The CD4 molecule is currently the object of intense interest and investigation both because of its role in normal T-cell function, and because of its role in HIV infection. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.

                    Viral protein U (VpU) of HIV-1 plays an important role in downregulation of the main HIV-1 receptor CD4 from the surface of infected cells. Physical binding of VpU to newly synthesized CD4 in the endoplasmic reticulum is an early step in a pathway leading to proteasomal degradation of CD4. Amino acids in both helices found in the cytoplasmic region of VpU in membrane-mimicking detergent micelles experience chemical shift perturbations upon binding to CD4, whereas amino acids between the two helices and at the C-terminus of VpU show no or only small changes, respectively. Paramagnetic spin labels were attached at three sequence positions of a CD4 peptide comprising the transmembrane and cytosolic domains of the receptor. VpU binds to a membrane-proximal region in the cytoplasmic domain of CD4.

                    CD4 別稱

                    CD4mut, []
                    CD4mut, [homo-sapiens]
                    CD4, [human]
                    Cd4,L3T4,Ly-4, [mouse]
                    L3T4,Ly-4, [mus-musculus]

                    CD4 相關文獻

                  • Farrar WL, et al. (1988) Characterization of CD4 glycoprotein determinant-HIV envelope protein interactions: perspectives for analog and vaccine development. Crit Rev Immunol. 8(4): 315-39.
                  • Biddison WE, et al. (1989) CD4 expression and function in HLA class II-specific T cells. Immunol Rev. 109: 5-15.
                  • Singh SK, et al. (2012) Mapping the interaction between the cytoplasmic domains of HIV-1 viral protein U and human CD4 with NMR spectroscopy. FEBS J. 279(19):3705-14.
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