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CD32b/FCGR2B/Fc gamma RIIB  Protein, Antibody, ELISA Kit, cDNA Clone

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表達宿主: Human Cells  
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10259-H08H-50
10259-H08H-100
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100 µg 
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表達宿主: Human Cells  
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10259-H27H-50
10259-H27H-100
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描述:   
表達宿主: Human Cells  
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10259-H27H-B-50
10259-H27H-B-20
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10259-H08C-50
10259-H08C-100
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表達宿主: Human Cells  
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80018-R08H-50
80018-R08H-100
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表達宿主: Human Cells  
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90014-C08H-50
90014-C08H-100
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100 µg 
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表達宿主: Human Cells  
  • Slide 1
90014-C27H-50
90014-C27H-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
90014-C27H-B-50
90014-C27H-B-20
50 µg 
20 µg 
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CD32b/FCGR2B/Fc gamma RIIB 相关研究领域

CD32b/FCGR2B/Fc gamma RIIB 相關信號通路

    CD32b/FCGR2B/Fc gamma RIIB 概述&蛋白信息

    CD32b/FCGR2B/Fc gamma RIIB 研究背景

    亞單位結構: Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN. {ECO:0000269|PubMed:15914856, ECO:0000269|PubMed:8327512, ECO:0000269|PubMed:9232445}.
    結構域: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    亞細胞定位: Cell membrane; Single-pass type I membrane protein.
    組織特異性: Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
    翻譯後修飾: Phosphorylated by the SRC-type Tyr-kinases LYN and BLK. {ECO:0000269|PubMed:8756631}.
    相關疾病 : DISEASE: Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.; DISEASE: Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:12115230, ECO:0000269|PubMed:20385827}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    相似的序列: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    CD32b/FCGR2B/Fc gamma RIIB 別稱

    CD32b/FCGR2B/Fc gamma RIIB 相關文獻

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