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CD22/Siglec-2  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
  • Slide 1
11958-H02H-50
11958-H02H-200
50 µg 
200 µg 
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表達宿主: Human Cells  
  • Slide 1
11958-H08H-50
11958-H08H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
11958-H08H1-50
11958-H08H1-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
51177-M02H-50
51177-M02H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
51177-M08H-50
51177-M08H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
81343-R02H-5
81343-R02H-20
81343-R02H-100
5 µg 
20 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
81343-R08H-5
81343-R08H-20
81343-R08H-100
5 µg 
20 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
90246-C08H-5
90246-C08H-20
90246-C08H-100
5 µg 
20 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
90246-C02H-20
90246-C02H-50
20 µg 
50 µg 
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CD22/Siglec-2 相關信號通路

CD22/Siglec-2 相關蛋白、抗體、cDNA基因、ELISA試劑盒

CD22/Siglec-2 概述&蛋白信息

CD22/Siglec-2 研究背景

基因概述: OMIM - description for CD22:
General information above from NCBI
亞單位結構: Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1.
結構域: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.
亞細胞定位: Cell membrane; Single-pass type I membrane protein.
組織特異性: B-lymphocytes.
翻譯後修飾: Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.
Phosphorylated on tyrosine residues by LYN (By similarity).
相似的序列: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
General information above from UniProt

CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. In addition to its potential role as a mediator of intercellular interactions, signal transduction through CD22 can activate B cells and modulate antigen receptor signaling in vitro. The phenotype of CD22-deficient mice suggests that CD22 is primarily involved in the generation of mature B cells within the bone marrow, blood, and marginal zones of lymphoid tissues. CD22 recruits the tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) to immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and inhibits B-cell receptor (BCR)-induced Ca2+ signaling on normal B cells. CD22 interacts specifically with ligands carrying alpha2-6-linked sialic acids. As an inhibitory coreceptor of the B-cell receptor (BCR), CD22 plays a critical role in establishing signalling thresholds for B-cell activation. Like other coreceptors, the ability of CD22 to modulate B-cell signalling is critically dependent upon its proximity to the BCR, and this in turn is governed by the binding of its extracellular domain to alpha2,6-linked sialic acid ligands. However, genetic studies in mice reveal that some CD22 functions are regulated by ligand binding, whereas other functions are ligand-independent and may only require expression of an intact CD22 cytoplasmic domain at the B-cell surface. CD19 regulates CD22 phosphorylation by augmenting Lyn kinase activity, while CD22 inhibits CD19 phosphorylation via SHP-1.

CD22/Siglec-2 別稱

SIGLEC2,SIGLEC-2, [homo-sapiens]
SIGLEC2,CD22,FLJ22814,MGC130020,SIGLEC-2, [human]
Lyb-8,A530093D23,Cd22,Lyb8, [mouse]
Lyb8,Lyb-8,A530093D23, [mus-musculus]

CD22/Siglec-2 相關文獻

  • Tedder TF, et al. (1997) CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. Annu Rev Immunol. 15: 481-504.
  • Tedder TF, et al. (2005) CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. Adv Immunol. 88: 1-50.
  • Fujimoto M, et al. (2007) B cell signaling and autoimmune diseases: CD19/CD22 loop as a B cell signaling device to regulate the balance of autoimmunity. J Dermatol Sci. 46(1): 1-9.
  • Walker JA, et al. (2008) CD22: an inhibitory enigma. Immunology. 123(3): 314-25.
  • Nitschke L. (2009) CD22 and Siglec-G: B-cell inhibitory receptors with distinct functions. Immunol Rev. 230(1): 128-43.
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