Anti-CD19 Antibody (FITC)

Cat: 11880-MM17-F
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Anti-CD19 Antibody (FITC) (Mouse Monoclonal antibody) General Information
Product name
Anti-CD19 Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human CD19
Immunogen
Recombinant Human CD19 Protein (Catalog#11880-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD19 (rh CD19; Catalog#11880-H08H; P15391; Met1-Lys291) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Mouse IgG1 Clone #17
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-CD19 Antibody (FITC) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD19 Antibody (FITC) (Mouse Monoclonal antibody) Images
Human CD19/B4/CVID3 Flow Cytometry (FC) 5297
Flow cytometric analysis of Human CD19 expression on human whole blood lymphocytes. Cells were stained with PE-conjugated anti-Human CD19 and FITC-conjugated anti-Human CD3. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.
Anti-CD19 Antibody (FITC) Alternative Names
Anti-B4 Antibody;Anti-CVID3 Antibody
CD19 Background Information

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 19 (CD19) is a member of CD system. CD19 is a cell surface molecule that assembles with the antigen receptor of B-cells. This results in a descent in threshold for antigen receptor-dependent stimulation. A simplified view holds that the ability of B-cells to respond to the various antigens in a specific and sensitive manner is achieved in the presence of low-affinity antigen receptors. CD19 primarily acts as a B-cell coreceptor in conjunction with CD21 and CD81. The formation of the receptor complex is induced by antigen and CD19, induced by exogenous antigen, has been found cytoplasmic tail phosphorylated and bind to sIg.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD19 molecule
References
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Carter RH, et al. (1992) CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science. 256 (5053): 105-7.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD19 Antibody Mouse Monoclonal ELISA(Det) 11880-MM15
    Anti-CD19 Antibody Rabbit Monoclonal ELISA,IP 11880-R303
    Anti-CD19 Antibody Rabbit Polyclonal ELISA 11880-RP01
    Anti-CD19 Antibody Mouse Monoclonal IHC-P 11880-MM25
    Anti-CD19 Antibody Rabbit Monoclonal IHC-P 11880-R109
    Anti-CD19 Antibody Mouse Monoclonal ELISA,ELISA(Cap) 11880-MM02
    Anti-CD19 Antibody Mouse Monoclonal ELISA 11880-MM05
    Anti-CD19 Antibody Mouse Monoclonal FCM 11880-MM17
    Anti-CD19 Antibody (PE) Mouse Monoclonal FCM 11880-MM17-P
    Anti-CD19 Antibody Rabbit Monoclonal ELISA,IP 11880-R410
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