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CD153/CD30L/TNFSF8   Protein, Antibody, ELISA Kit, cDNA Clone

描述: Active  
表達宿主: Human Cells  
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10040-H01H-5
10040-H01H-50
10040-H01H-100
5 µg 
50 µg 
100 µg 
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表達宿主: Human Cells  
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10040-HNCH-200
10040-HNCH-50
200 µg 
50 µg 
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表達宿主: Human Cells  
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80148-R01H-50
80148-R01H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
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80148-RNCH-50
80148-RNCH-100
50 µg 
100 µg 
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表達宿主: Human Cells  
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90091-C01H-50
90091-C01H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
90091-C07H-50
90091-C07H-100
50 µg 
100 µg 
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CD153/CD30L/TNFSF8  相關信號通路

CD153/CD30L/TNFSF8  相關蛋白、抗體、cDNA基因、ELISA試劑盒

CD153/CD30L/TNFSF8  概述&蛋白信息

CD153/CD30L/TNFSF8  研究背景

基因概述: The protein encoded by TNFSF8 gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for TNFSF8 gene. [provided by RefSeq, Nov 2011]
General information above from NCBI
亞單位結構: Homotrimer (Probable).
亞細胞定位: Membrane; Single-pass type II membrane protein.
相似的序列: Belongs to the tumor necrosis factor family.C
General information above from UniProt

CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. CD30L is a type-II membrane glycoprotein expressed on activated T cells, stimulated monocyte-macrophages, granulocytes, eosinophils, and some Burkitt-like lymphoma cell lines. CD30L is capable of transducing signals through CD30 on different CD30+ lymphoma cell lines, and mediates pleiotropic biologic effects including cell proliferation, activation, differentiation, as well as cell death by apoptosis. CD30-CD30 ligand interaction has been suggested to have a pathophysiologic role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune response. Thus, CD153 and its receptor CD30 are regarded as therapeutic targets in hematologic malignancies, autoimmune and inflammatory diseases.

CD153/CD30L/TNFSF8  別稱

CD153/CD30L/TNFSF8  相關文獻

  • Hargreaves PG, et al. (2002) Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30. Eur J Immunol. 32(1): 163-73.
  • Blazar BR, et al. (2004) CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease. J Immunol. 173(5): 2933-41.
  • Oflazoglu E, et al. (2009) Targeting CD30/CD30L in oncology and autoimmune and inflammatory diseases. Adv Exp Med Biol. 647: 174-85.
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