快速訂購

留言    收藏

CD147 / EMMPRIN / Basigin 抗體, 兔單抗

  • CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunohistochemistry
  • CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunohistochemistry
  • CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunohistochemistry
  • CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunohistochemistry
  • CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunohistochemistry
  • CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb
  • CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunohistochemistry
  • CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunofluorescence
  • CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunofluorescence
  • CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Western blot
  • CD147 / EMMPRIN Antibody, Rabbit MAb, Flow cytometric analysis
產品資料評論相關產品實驗方法
 CD147/BSG 抗體產品資訊
免疫原:Recombinant Human CD147 protein (Catalog#10186-H08H)
Clone ID:125
Ig類型:Rabbit IgG
濃度:
內毒素:
緩衝液:0.2 μm filtered solution in PBS
抗體製備方法:This antibody was obtained from a rabbit immunized with purified, recombinant Human CD147 / Basigin (rh CD147; Catalog#10186-H08H; NP_940991.1; Met 1-His 205).
 CD147/BSG Antibody WB Application Image
 CD147/BSG Antibody IHC Application Image
CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human CD147 in human esophagus with rabbit monoclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections). The image showing membrane staining of squamous epithelium cell. The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human CD147 in human gastric cancer with rabbit monoclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections). The image showing membrane staining of epithelium cell.
CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human CD147 in human liver with rabbit monoclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections). The image showing membrane staining of hepatocyte.
CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human CD147 in human placenta with rabbit monoclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections). The image showing positive staining of trophoblast.
CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human CD147 in human rectal cancer with rabbit monoclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections). The image showing membrane staining of epithelium cell in intestinal gland.
CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human CD147 in human stomach with rabbit monoclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections). The image showing membrane staining of epithelium cell.
CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunofluorescence
[點擊查看大圖]
Caption:
Immunofluorescence staining of CD147 in monkey stomach with rabbit monoclonal antibody (1μg/mL, frozen section). The image showing membrane staining of gastric gland cell. The right panel: merge with DAPI
 CD147/BSG Antibody IF Application Image
CD147 / EMMPRIN / Basigin Antibody, Rabbit MAb, Immunofluorescence
[點擊查看大圖]
Caption:
Immunofluorescence staining of human CD147 in HeLa cells with rabbit monoclonal antibody (5 µg/mL). The image showing membrane staining of HeLa cells.
 CD147/BSG Antibody FC Application Image
CD147 / EMMPRIN Antibody, Rabbit MAb, Flow cytometric analysis
[點擊查看大圖]
Caption:
Analysis of anti-CD147 reactivity on HeLa cells.
 CD147/BSG Antibody IP Application Image
Other CD147/BSG Antibody Products
CD147/EMMPRIN/Basigin 研究背景

CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.

 CD147/EMMPRIN/Basigin 參考資料
  • Tang Y, et al. (2004) Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN. Mol Cancer Res. 2(2): 73-80.
  • Wilson MC, et al. (2005) Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem. 280(29): 27213-21.
  • Curtin KD, et al. (2005) Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture. J Cell Sci. 118(Pt 12): 2649-60.
  • Zhu H, et al. (2009) A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity. Cancer Biol Ther. 8(11): 1035-44. Zhu H, et al. (2009) A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity. Cancer Biol Ther. 8(11): 1035-44.
  • Seizer P, et al. (2009) EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction. Thromb Haemost. 101(4): 682-6.
  • Moonsom S, et al. (2010) A Competitive ELISA for Quantifying Serum CD147: Reduction of Soluble CD147 Levels in Cancer Patient Sera. Hybridoma (Larchmt). 29(1): 45-52.
  • Product nameProduct name
    Size / Price
    貨號: 10186-R125-50
    目錄價: 
    單價:      (You Save: )

    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”