CD137 (Protein|Antibody|cDNA Clone|ELISA Kit)

All CD137 reagents are produced in house and quality controlled, including 3 CD137 Antibody, 65 CD137 Gene, 11 CD137 Lysate, 11 CD137 Protein, 3 CD137 qPCR. All CD137 reagents are ready to use.

Recombinant CD137 proteins are expressed by HEK293 Cells with fusion tags as C-His, C-rabbit IgG-Fc, C-human IgG1-Fc, C-human IgG1-Fc & His, C-His & C-human IgG1-Fc.

CD137antibodies are validated with different applications, which are ELISA.

CD137cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD137 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

CD137 Protein (11)

Species

CD137 Protein, Mouse, Recombinant (Fc Tag)

50811-M02H

Expression host: HEK293 Cells

Mouse 4-1BB/TNFRSF9/CD137 Protein 11923

CD137 Protein, Rhesus, Recombinant (His Tag)

90847-K08H

Expression host: HEK293 Cells

Rhesus 4-1BB/TNFRSF9/CD137 Protein 6417

CD137 Protein, Human, Recombinant (His & Fc Tag)

10041-H03H

Expression host: HEK293 Cells

Human 4-1BB/TNFRSF9/CD137 Protein 8324

CD137 Protein, Mouse, Recombinant (His Tag)

50811-M08H

Expression host: HEK293 Cells

Mouse 4-1BB/TNFRSF9/CD137 Protein 17899

CD137 Protein, Canine, Recombinant (Fc Tag)

70095-D02H

Expression host: HEK293 Cells

Canine 4-1BB/TNFRSF9/CD137 Protein 12282

CD137 Protein, Human, Recombinant, Biotinylated

10041-H03H-B

Expression host: HEK293 Cells

Human 4-1BB/TNFRSF9/CD137 Protein 18554

CD137 Protein, Human, Recombinant (His Tag), Biotinylated

10041-H08H-B

Expression host: HEK293 Cells

Human 4-1BB/TNFRSF9/CD137 Protein 18555

CD137 Protein, Mouse, Recombinant (Fc Tag)

50811-M31H

Expression host: HEK293 Cells

Mouse 4-1BB/TNFRSF9/CD137 Protein 17855

CD137 Protein, Canine, Recombinant (His Tag)

70095-D08H

Expression host: HEK293 Cells

Canine 4-1BB/TNFRSF9/CD137 Protein 12283

CD137 Protein, Rhesus, Recombinant (Fc Tag)

90847-K02H

Expression host: HEK293 Cells

Rhesus 4-1BB/TNFRSF9/CD137 Protein 6416

CD137 Protein, Human, Recombinant (His Tag)

10041-H08H

Expression host: HEK293 Cells

Human 4-1BB/TNFRSF9/CD137 Protein 8325
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CD137 Antibody (3)

Application
Clonality
Host

Anti-CD137 Antibody

10041-T16

Application: ELISA

Clonality: PAb

Anti-CD137 Antibody

10041-RP01

Application: ELISA

Clonality: PAb

Anti-CD137 Antibody

10041-RP02

Application: ELISA

Clonality: PAb

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CD137 cDNA Clone (65)

Mouse
Human
Rhesus
Canine
Rat

CD137 qPCR Primer (3)

CD137 Lysate (11)

CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

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Antibody
Gene
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