Anti-RON Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human CD136 / MST1R Protein (Catalog#11608-H08H)
Produced in rabbits immunized with purified, recombinant Human CD136 / MST1R (rh CD136 / MST1R; Catalog#11608-H08H; Q04912; Met1-Leu571). CD136 / MST1R specific IgG was purified by Human CD136 / MST1R affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-RON Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-RON Antibody (Rabbit Polyclonal antibody) Images
Immunochemical staining of human CD136 in human skin with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).
Immunochemical staining of human CD136 in human stomach with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).
Anti-RON Antibody Alternative Names
Anti-CD136 Antibody;Anti-CDw136 Antibody;Anti-PTK8 Antibody;Anti-RON Antibody
RON Background Information
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As tyrosine kinase receptor comprised of an extra-cellular domain, MST1R protein contains the ligand binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in vivo during injury. This assessment of gene expression indicates the importance of genetic factors in contributing to lung injury, and points to strategies for intervention in the progression of inflammatory diseases. It had been shown that MST1R/CD136 plays a critical role in Ni-induced lung injury in mice. The overexpression of MSP, MT-SP1, and MST1R was a strong independent indicator of both metastasis and death in human breast cancer patients and significantly increased the accuracy of an existing gene expression signature for poor prognosis. Stimulation of MST1R leads to its transphosphorylation and the ultimate activation of numerous intracellular signaling pathways, such as the classical mitogen-activated protein kinase pathway, the phosphotidylinositol (PI)3-kinase pathway, and the JNK pathway.
macrophage stimulating 1 receptor
Ronsin C, et al. (1993) A novel putative receptor protein tyrosine kinase of the met family. Oncogene. 8: 1195-1202.McDowell SA, et al. (2002) The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury. Am J Respir Cell Mol Biol. 26(1): 99-104.Angeloni D, et al. (2003) C to A single nucleotide polymorphism in intron 18 of the human MST1R (RON) gene that maps at 3p21.3. Mol Cell Probes. 17(2-3): 55-7.Mallakin A, et al. (2006) Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury. Am J Respir Cell Mol Biol. 34(1): 15-27.Welm AL, et al. (2007) The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans. Proc Natl Acad Sci U S A. 104(18): 7570-5.