All CD13 reagents are produced in house and quality controlled, including 11 CD13 Antibody, 18 CD13 Gene, 1 CD13 IPKit, 2 CD13 Lysate, 2 CD13 Protein, 2 CD13 qPCR. All CD13 reagents are ready to use.
Recombinant CD13 proteins are expressed by HEK293 Cells with fusion tags as C-His.
CD13antibodies are validated with different applications, which are ELISA, IHC-P, ICC/IF, IF, WB, IP.
CD13cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD13 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Aminopeptidase N (ANPEP or APN), also known as CD13, is a cell-surface metalloprotease located in the small-intestinal and renal microvillar membrane, as well as other plasma membranes. It belongs to the peptidase M1 family. CD13 plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases and is involved in the metabolism of regulatory peptides by diverse cell types. CD13/APN is a potent regulator of angiogenesis which is essential for tumor invasion and metastasis, and its transcription in activated endothelial cells is induced by angiogenic growth factors via the RAS/MAPK pathway. In addition, this enzyme has been shown to participate in antigen processing and presentation, and accordingly, defects in this gene appear to be a cause of various types of leukemia or lymphoma and carcinomas.