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CD13 / ANPEP  Protein, Antibody, ELISA Kit, cDNA Clone

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表達宿主: Human Cells  
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10051-H08H-10
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表達宿主: Human Cells  
50001-M08H-20
50001-M08H-10
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10 µg 
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CD13 / ANPEP 相关研究领域

CD13 / ANPEP 相關信號通路

    CD13 / ANPEP 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    CD13 / ANPEP 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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    CD13 / ANPEP 概述&蛋白信息

    CD13 / ANPEP 研究背景

    基因概述: Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in ANPEP gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    催化活性: Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide. {ECO:0000269|PubMed:22932899}.
    輔因數: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:22932899}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:22932899};
    亞單位結構: Homodimer. Interacts with the S1 domain of HCoV-229E spike protein. {ECO:0000269|PubMed:12551991, ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:22932899, ECO:0000269|PubMed:6149934}.
    結構域: Amino acids 260-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/human chimeric studies) and more specifically amino acids 288-295 (mutagenesis studies).
    亞細胞定位: Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol {ECO:0000305}. Note=A soluble form has also been detected.
    組織特異性: Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
    誘導: Estradiol and IL8/interleukin-8 decrease enzymatic activity in vitro in endometrial stromal cells by 40% and 30%, respectively. {ECO:0000269|PubMed:11384645}.
    翻譯後修飾: Sulfated. {ECO:0000250}.; N- and O-glycosylated. {ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:1705556, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22932899, ECO:0000269|PubMed:9056417}.; May undergo proteolysis and give rise to a soluble form.
    相似的序列: Belongs to the peptidase M1 family. {ECO:0000305}.
    General information above from UniProt

    Aminopeptidase N (ANPEP or APN), also known as CD13, is a cell-surface metalloprotease located in the small-intestinal and renal microvillar membrane, as well as other plasma membranes. It belongs to the peptidase M1 family. CD13 plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases and is involved in the metabolism of regulatory peptides by diverse cell types. CD13/APN is a potent regulator of angiogenesis which is essential for tumor invasion and metastasis, and its transcription in activated endothelial cells is induced by angiogenic growth factors via the RAS/MAPK pathway. In addition, this enzyme has been shown to participate in antigen processing and presentation, and accordingly, defects in this gene appear to be a cause of various types of leukemia or lymphoma and carcinomas.

    CD13 / ANPEP 別稱

    p150,APN,CD13,LAP1,PEPN,GP150, [homo-sapiens]
    ANPEP,APN,CD13,GP150,PEPN,p150,LAP1, [human]
    Cd13,Lap1,Lap-1,P150,APN, [mouse]
    APN,P150,AP-M,AP-N,Cd13, [mus-musculus]

    CD13 / ANPEP 相關文獻

  • Pasqualini R, et al. (2000) Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.Cancer Res. 60(3): 722-7.
  • Mabjeesh SJ, et al. (2005) Aminopeptidase N gene expression and abundance in caprine mammary gland is influenced by circulating plasma peptide. J Dairy Sci. 88(6): 2055-64.
  • Dunkel B, et al. (2009) Neutrophil and platelet activation in equine recurrent airway obstruction is associated with increased neutrophil CD13 expression, but not platelet CD41/61 and CD62P or neutrophil-platelet aggregate formation. Vet Immunol Immunopathol. 131(1-2): 25-32.
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