CCL18 Protein, Human, Recombinant (His Tag)

1/1
Price:
Size:
Number:

CCL18 Protein, Human, Recombinant (His Tag): Product Information

Purity
> 95 % as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
Testing in progress
Protein Construction
A DNA sequence encoding human CCL18 (NP_002979.1) (Ala21-Ala89) was expressed with a polyhistidine tag at the C-terminus.
Accession#
Expressed Host
Yeast
Species
Human
Predicted N Terminal
Ala 21
Molecule Mass
The recombinant human CCL18 consists of 79 amino acids and predicts a molecular mass of 9.2 KDa. It migrates as an approximately 9 KDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CCL18 Protein, Human, Recombinant (His Tag): Images

CCL18 Protein, Human, Recombinant (His Tag): Alternative Names

AMAC-1 Protein, Human; AMAC1 Protein, Human; CCL18 Protein, Human; CKb7 Protein, Human; DC-CK1 Protein, Human; DCCK1 Protein, Human; MIP-4 Protein, Human; MIP4 Protein, Human; PARC Protein, Human; SCYA18 Protein, Human

CCL18 Background Information

CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. CCL18 chemokine has an important role in chemokine-mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. (CCL18) is predominantly secreted by M2-tumor associated macrophages (TAMs) and promotes malignant behaviors of various human cancer types. CCL18 has a correlation with cardiac function in patients with AAMI and it might be considered as an indicator of poor LVEF in patients with AAMI. Circulating and WAT-secreted CCL18 correlates with insulin resistance and metabolic risk score. Because CCL18 is macrophage-specific and associates with adipose immune gene expression, it may constitute a marker of WAT inflammation. Macrophages are thought to be the main source of CCL18, and the effect of pirfenidone, an anti-fibrotic agent for idiopathic pulmonary fibrosis, on the expression of CCL18 in macrophages warrants investigation.
Full Name
chemokine (C-C motif) ligand 18
Add to Cart Successfully Add to Cart Failed Shopping cart is being updated, please wait