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C8B  Protein, Antibody, ELISA Kit, cDNA Clone

C8B 相关研究领域

C8B 相關信號通路

    C8B 概述&蛋白信息

    C8B 研究背景

    亞單位結構: Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. {ECO:0000269|PubMed:21454577, ECO:0000269|PubMed:7440581}.
    亞細胞定位: Secreted.
    翻譯後修飾: N-glycosylated; contains one or two bound glycans. Not O-glycosylated. {ECO:0000269|PubMed:10551839, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:2820472}.
    相關疾病 : DISEASE: Complement component 8 deficiency, 2 (C8D2) [MIM:613789]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    相似的序列: Belongs to the complement C6/C7/C8/C9 family. {ECO:0000305}.; Contains 1 EGF-like domain. {ECO:0000305}.; Contains 1 LDL-receptor class A domain. {ECO:0000255|PROSITE-ProRule:PRU00124}.; Contains 1 MACPF domain. {ECO:0000255|PROSITE-ProRule:PRU00745}.; Contains 2 TSP type-1 domains. {ECO:0000255|PROSITE-ProRule:PRU00210}.
    General information above from UniProt

    C8B 別稱

    C8B 相關文獻

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