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C5AR1/C5R1/CD88  Protein, Antibody, ELISA Kit, cDNA Clone

C5AR1/C5R1/CD88 相关研究领域

C5AR1/C5R1/CD88 相關信號通路

C5AR1/C5R1/CD88 概述&蛋白信息

C5AR1/C5R1/CD88 研究背景

亞單位結構: Homodimer. May also form higher-order oligmers (PubMed:12835319). Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR (PubMed:12464600). Interacts (via N-terminal domain) with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response (PubMed:15153520, PubMed:15542591, PubMed:21706042). {ECO:0000269|PubMed:12464600, ECO:0000269|PubMed:12835319, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:15542591, ECO:0000269|PubMed:21706042, ECO:0000303|PubMed:12835319}.
亞細胞定位: Cell membrane {ECO:0000269|PubMed:12464600}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000269|PubMed:12464600}. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. {ECO:0000269|PubMed:12464600}.
翻譯後修飾: Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist (PubMed:11342590). Sulfation at Tyr-14 is important for CHIPS binding (PubMed:21706042). {ECO:0000269|PubMed:11342590, ECO:0000303|PubMed:21706042}.; Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to the ligand. The key residues involved in this process are Ser-334 and Ser-338. {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:12464600}.
相似的序列: Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
General information above from UniProt

C5AR1/C5R1/CD88 別稱

C5a anaphylatoxin receptor 1,C5AR,C5R1,CD88,C5aR,C5r1,Cd88,D7Msu1, []
C5A,C5AR,C5R1,CD88, [homo-sapiens]
C5aR,C5r1,Cd88,D7Msu1, [mus-musculus]

C5AR1/C5R1/CD88 相關文獻

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