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C1QBP/HABP1  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: E. coli  
11874-H08E-50
11874-H08E-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
表達宿主: E. coli  
50199-M07E-50
50199-M07E-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

C1QBP/HABP1 相关研究领域

C1QBP/HABP1 相關信號通路

C1QBP/HABP1 相關蛋白、抗體、cDNA基因、ELISA試劑盒

C1QBP/HABP1 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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C1QBP/HABP1 概述&蛋白信息

C1QBP/HABP1 研究背景

基因概述: The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this C1QBP gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. C1QBP has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein.
General information above from NCBI
亞單位結構: Homotrimer; three monomers form a donut-shaped structure with an unusually asymmetric charge distribution on the surface. Interacts with CDK13, HRK, VTN, NFYB, ADRA1B, FOXC1, DDX21, DDX50, NCL, SRSF1, SRSF9 and CDKN2A isoform smARF. Interacts with CD93; the association may represent a cell surface C1q receptor. Interacts with KRT1; the association represents a cell surface kininogen receptor. Interacts with CD209; the interaction is indicative for a C1q:C1QBP:CD209 signaling complex. Interacts with FBL and RRP1; the respective interactions with C1QBP are competetive. Probably associates with the mitoribosome. Interacts with MAVS; the interaction occurs upon viral transfection. Interacts with PPIF. Interacts with Rubella virus capsid protein; the interaction occurs in mitochondria. Interacts with Rubella virus protease p150, Staphylococcus aureus protein A/spa, HIV-1 Tat and HCV core protein. Interacts with U2AF1L4. {ECO:0000250|UniProtKB:O35658, ECO:0000269|PubMed:10022843, ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:10823864, ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:12034482, ECO:0000269|PubMed:15031724, ECO:0000269|PubMed:15243141, ECO:0000269|PubMed:16537587, ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:17486078, ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:20950273, ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:21544310, ECO:0000269|PubMed:22238231, ECO:0000269|PubMed:22700724, ECO:0000269|PubMed:8900153, ECO:0000269|PubMed:9233640}.
亞細胞定位: Mitochondrion matrix. Nucleus. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted. Cytoplasm. Nucleus, nucleolus. Note=Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes.
組織特異性: Expressed on cell surface of peripheral blood cells (at protein level); Surface expression is reported for macrophages and monocyte-derived dendritic cells. {ECO:0000269|PubMed:12574814, ECO:0000269|PubMed:8662673}.
誘導: Enhanced cell surface expression upon platelet and monocyte activation. {ECO:0000269|PubMed:12574814, ECO:0000269|PubMed:16177118}.
相似的序列: Belongs to the MAM33 family. {ECO:0000305}.
General information above from UniProt

Hyaluronan binding protein 1 (HABP1), also known as p32 or gC1qR, is a ubiquitously expressed multifunctional phospho-protein implicated in cell signalling. Hyaluronan-binding protein 1 (HABP1) /p32/gC1qR was characterized as a highly acidic and oligomeric protein, which binds to different ligands like hyaluronan, C1q, and mannosylated albumin. The role of hyaluronan binding protein 1 (HABP1) in cell signaling was investigated and in vitro. HABP1 overexpressing cells showed extensive vacuolation and reduced growth rate, which was corrected by frequent medium replenishment. Further investigation revealed that HABP1 overexpressing cells undergo apoptosis, and they failed to enter into the S-phase. The sperm surface HABP1 level can be correlated with the degree of sperm motility.Hyaluronan binding protein 1 (HABP1) was reported to be present on human sperm surface and its involvement in fertilization has already been elucidated: decreased HABP1 level may be associated with low motility of sperms, which in turn might cause infertility in the patient. HABP1 also is an endogenous substrate for MAP kinase and upon mitogenic stimulation it is translocated to the nucleus in a MAP kinase-dependent manner.

C1QBP/HABP1 別稱

p32,HABP1,gC1qR,GC1QBP,SF2p32,gC1Q-R, [homo-sapiens]
SF2p32,C1QBP,GC1QBP,gC1qR,gC1Q-R,HABP1,p32, [human]
AA407365,C1qbp,D11Wsu182e,AA986492,DN-393H17.2,gC1qBP,HABP1,P32, [mouse]
P32,HABP1,gC1qBP,AA407365,AA986492,D11Wsu182e, [mus-musculus]
gC1qR,Habp1, [Rat]

C1QBP/HABP1 相關文獻

  • Meenakshi J, et al. (2003) Constitutive expression of hyaluronan binding protein 1 (HABP1/p32/gC1qR) in normal fibroblast cells perturbs its growth characteristics and induces apoptosis. Biochemicaland Biophysical Research Communication. 300(3): 686-93.
  • Majumdar M, et al. (2002) Hyaluronan Binding Protein 1 (HABP1) /C1QBP/p32 Is an Endogenous Substrate for MAP Kinase and Is Translocated to the Nucleus upon Mitogenic Stimulation. Biochemical and Biophysical Research Communications. 291(4): 829-37.
  • Ghosh I, et al. (2002) Reduction in the level of hyaluronan binding protein 1 (HABP1) is associated with loss of sperm motility. Journal of Reproductive Immunology. 53(1-2): 45-54.
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