All C1 inhibitor reagents are produced in house and quality controlled, including 5 C1 inhibitor Antibody, 2 C1 inhibitor ELISA, 52 C1 inhibitor Gene, 1 C1 inhibitor IPKit, 2 C1 inhibitor Lysate, 2 C1 inhibitor Protein, 1 C1 inhibitor qPCR. All C1 inhibitor reagents are ready to use.
Recombinant C1 inhibitor proteins are expressed by HEK293 Cells with fusion tags as C-His.
C1 inhibitorantibodies are validated with different applications, which are WB, ELISA, IHC-P, ELISA(Cap), ELISA(Det), IP.
C1 inhibitorcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each C1 inhibitor of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
C1 inhibitorELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine proteinase inhibitor (serpin) that regulates activation of both the complement and contact systems. By its C-terminal part (serpin domain), characterized by three beta-sheets and an exposed mobile reactive loop, C1-INH binds, and blocks the activity of its target proteases. The N-terminal end (nonserpin domain) confers to C1-INH the capacity to bind lipopolysaccharides and E-selectin. Owing to this moiety, C1-INH intervenes in regulation of the inflammatory reaction. The heterozygous deficiency of C1-INH results in hereditary angioedema (HAE). Owing to its ability to modulate the contact and complement systems and the convincing safety profile, plasma-derived C1 inhibitor is an attractive therapeutic protein to treat inflammatory diseases other than HAE. Deficiency of C1 inhibitor results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa. C1 inhibitor may prove useful in a variety of other diseases including septic shock, reperfusion injury, hyperacute transplant rejection, traumatic and hemorrhagic shock, and the increased vascular permeability associated with thermal injury, interleukin-2 therapy and cardiopulmonary bypass.