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BST2  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
13370-H01H-50
13370-H01H-20
50 µg 
20 µg 
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表達宿主: Human Cells  
13370-H07H-50
13370-H07H-20
50 µg 
20 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
51043-M07H-20
51043-M07H-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
51043-M01H-50
51043-M01H-20
50 µg 
20 µg 
Add to Cart
  • Slide 1

BST2 相关研究领域

BST2 相關信號通路

    BST2 概述&蛋白信息

    BST2 研究背景

    基因概述: Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis.
    General information above from NCBI
    亞單位結構: Parallel homodimer; disulfide-linked. May form homotetramers under reducing conditions. Isoform 1 and isoform 2 form homodimers and also heterodimers with each other. Dimerization is essential for its antiviral activity. Interacts (via cytoplasmic domain) with ARHGAP44 (By similarity). Interacts with MMP14 (via C-terminal cytoplasmic tail). Interacts with LILRA4/ILT7. Interacts (via transmembrane domain) with HIV-1 VPU (via transmembrane domain). Interacts with HIV-2 ENV and ebola GP protein. {ECO:0000250, ECO:0000269|PubMed:10329429, ECO:0000269|PubMed:19179289, ECO:0000269|PubMed:19564354, ECO:0000269|PubMed:19737401, ECO:0000269|PubMed:19740980, ECO:0000269|PubMed:19837671, ECO:0000269|PubMed:19879838, ECO:0000269|PubMed:20399176, ECO:0000269|PubMed:20880831, ECO:0000269|PubMed:20940320, ECO:0000269|PubMed:22065321, ECO:0000269|PubMed:23028328}.
    結構域: The extracellular coiled coil domain forms an extended 170 A long semi-flexible rod-like structure important for virion retention at the cell surface and prevention of virus spreading. {ECO:0000269|PubMed:20399176}.
    亞細胞定位: Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Late endosome. Membrane raft. Cytoplasm. Apical cell membrane {ECO:0000250}. Note=Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts, and the trans-Golgi network. HIV-1 VPU and HIV-2 ENV can target it to the trans-Golgi network thus sequestering it away from virus assembly sites on the cell membrane. Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. Forms a complex with MMP14 and localizes to the cytoplasm.
    組織特異性: Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highly expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level). {ECO:0000269|PubMed:10329429, ECO:0000269|PubMed:16157322}.
    誘導: By type I interferons. Down-regulated by viral antagonistic factors which include: HIV-1 VPU protein, HIV-2 ENV protein, KSHV K5 protein and ebola virus GP protein. VPU and ENV antagonize its function by targeting it to the trans-Golgi network, sequestering it away from virus assembly sites on the cell membrane. VPU also acts as an adapter molecule linking it to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, inducing its ubiquitination and subsequent proteasomal degradation. K5 ubiquitinates it leading to its targeting to late endosomes and degradation. {ECO:0000269|PubMed:16157322, ECO:0000269|PubMed:19179289, ECO:0000269|PubMed:19740980, ECO:0000269|PubMed:19837671, ECO:0000269|PubMed:23028328}.
    翻譯後修飾: Monoubiquitinated by KSHV E3 ubiquitin-protein ligase K5, leading to its targeting to late endosomes and degradation. {ECO:0000269|PubMed:20419159}.; The GPI anchor is essential for its antiviral activity.
    相似的序列: Belongs to the tetherin family. {ECO:0000305}.
    General information above from UniProt

    BST2 別稱

    CD317,TETHERIN, [homo-sapiens]
    bone marrow stromal antigen 2,HM1.24 antigen,2310015I10Rik,Bst-2,C87040,DAMP-1,DAMP-1 protein homolog,GREG, [human]
    GREG,Bst-2,CD317,C87040,DAMP-1,2310015I10Rik, [mus-musculus]

    BST2 相關文獻

  • Ishikawa J, et al. (1995) Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics. 26 (3): 527-34.
  • Viswanathan K, et al. (2011) BST2/Tetherin enhances entry of human cytomegalovirus. PLoS Pathog. 7(11):e1002332.
  • Gifford RJ. (2011) No trespassing: ancient BST2 deletion confers protection against simian immunodeficiency virus infection of humans. Hum Mutat. 32(11).
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