All BAFF reagents are produced in house and quality controlled, including 5 BAFF Antibody, 40 BAFF Gene, 2 BAFF IPKit, 4 BAFF Lysate, 5 BAFF Protein, 2 BAFF qPCR. All BAFF reagents are ready to use.
Recombinant BAFF proteins are expressed by HEK293 Cells, E. coli with fusion tags as N-human IgG1-Fc, Native, N-cleavage.
BAFFantibodies are validated with different applications, which are WB, ELISA, IP, FCM.
BAFFcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each BAFF of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). These receptors is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. Thus, it acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells. Overexpression of BLyS in mice can lead to clinical and serological features of systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). BLyS as an attractive therapeutic target in human rheumatic diseases. The ability of BLyS to regulate both the size and repertoire of the peripheral B cell compartment raises the possibility that BLyS and antagonists thereof may form the basis of a therapeutic trichotomy. As an agonist, BLyS protein may enhance humoral immunity in congenital or acquired immunodeficiencies such as those resulting from viral infection or cancer therapy.