All B7-H4 reagents are produced in house and quality controlled, including 3 B7-H4 Antibody, 28 B7-H4 Gene, 7 B7-H4 Lysate, 7 B7-H4 Protein, 2 B7-H4 qPCR. All B7-H4 reagents are ready to use.
Recombinant B7-H4 proteins are expressed by Baculovirus-Insect Cells, HEK293 Cells with fusion tags as C-His, C-cleavage, C-human IgG1-Fc, C-mouse IgG1-Fc.
B7-H4antibodies are validated with different applications, which are ELISA, IHC-P.
B7-H4cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each B7-H4 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type? membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7X / VTCN1 / B7H4 plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7X / VTCN1 / B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6 / interleukin-6 and IL10 / interleukin-10 and inhibited by CSF2 / GM-CSF and IL4 / interleukin-4 on antigen-presenting cells.
Immune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IHC Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets