Text Size:AAA


Sino biological offers a wide selection of tools for B cell related research. These include high-purity recombinant proteins, high-specific antibodies and ORF cDNA clones.

Product CategoriesProteinsAntibodiesELISA KitscDNA Clones
Number of Products

B細胞 Related Products Index

    B細胞 Related Products by Product Type

    B細胞 By Species

    B細胞 by Signaling Pathways

    B細胞 Background

    B Cells play an important role in the humoral immune response of adaptive immunity. The abbreviation "B", in B cell, comes from the bursa of Fabricius in birds, where they mature. While in most mammals B cells are produced in the bone marrow, and migrate to the spleen where they differentiate into mature B cells. As essential components of the adaptive immune system, B cells are responsible for producing antibodies against specific antigens.

    B cell development occurs through several stages. The earliest stage is called the B progenitor cell; lymphoid progenitor cells receive signals from bone marrow stromal cells to begin B cell development. Subsequent stages include the pro-B cell; the pre-B cell; the immature B cell; the virgin or mature B cell; the activated B cell; the B lymphoblast; the plasma B cell or the memory B cell. Each B cell has a unique receptor protein (referred to as the B cell receptor) on its surface that will bind to one particular antigen. The B cell receptor allows the distinction of B cells from other types of lymphocyte, as well as being the main protein involved in B cell activation. Following antigen recognition by B cell receptors, the antigen is engulfed into B cell and processed via receptor-mediated endocytosis. The antigen is digested into fragments, which are then displayed at the cell surface nestled inside a class II histocompatibility molecule. B cells function as antigen presenting cells (APCs) to T cells. Helper T cells specific for this structure bind the B cell and secretes cytokines that activate the B cell. These cytokines stimulate B cell proliferation and differentiation into plasma cell that secrete the soluble B cell receptors, which we now call antibodies. A small number of B cells further develop into memory B cells, which express high affinity surface immunoglobulins (mainly IgG), survive for a longer period of time, and enable the rapid secondary response.

    B細胞 References

      1. Waldmann H, et al. (1975) B cell activation. Transplant Rev. 23:213-22.
      2. Freedman AS,et al. (1987) B cell development in chronic lymphocytic leukemia. Semin Hematol. 24(4):230-9.
      3. Dorshkind K,et al. (1992) Regulation of B cell differentiation by bone marrow stromal cells. Int J Cell Cloning. 10(1):12-7.
      4. Tedder TF. (2009) CD19: a promising B cell target for rheumatoid arthritis. Nat Rev Rheumatol. 5(10):572-7.
      5. Khan WN. (2009) B cell receptor and BAFF receptor signaling regulation of B cell homeostasis. J Immunol. 183(6):3561-7.