Anti-H7N9 Hemagglutinin / HA Antibody, Mouse MAb


Anti-H7N9 Hemagglutinin / HA Antibody, Mouse MAb (Mouse Monoclonal antibody) General Information

Product name
Anti-H7N9 Hemagglutinin / HA Antibody, Mouse MAb
Validated applications
WB,ELISA,IHC-P,FCM,ICC/IF,IP (Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.)
Application notes
(Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.)
H7N9 Hemagglutinin / HA
Has cross-reactivity in ELISA with
H7N9 (A/Anhui/1/2013) HA
H7N9 (A/Shanghai/1/2013) HA
H3N2 (A/Brisbane/10/2007) HA
H4N6 (A/mallard/Ohio/657/2002) HA
H10N3 (A/duck/Hong Kong/786/1979) HA
H13N8 (A/black-headed gull/Netherlands/1/00) HA
No cross-reactivity in ELISA with
H1N1 (A/California/07/2009) HA
H5N1 (A/Anhui/1/2005) HA
H7N7 (A/Netherlands/219/03) HA
H9N2 (A/Hong Kong/1073/99) HA
H2N2 (A/Canada/720/2005) HA
H6N1 (A/northern shoveler/California/HKWF115/2007) HA
H8N4 (A/pintail duck/Alberta/114/1979) HA
H11N2 (A/duck/Yangzhou/906/2002) HA
H12N5 (A/green-winged teal/ALB/199/1991) HA
H15N8 (A/duck/AUS/341/1983) HA
H16N3 (A/black-headed gull/Sweden/5/99) HA
Influenza B virus (B/Florida/4/2006) HA
Monoclonal Mouse IgG2b Clone #04
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-H7N9 Hemagglutinin / HA Antibody, Mouse MAb (Mouse Monoclonal antibody) Validated Applications

Application Dilution
WB his antibody can be used at 1:1000-1:2000 with the appropriate secondary reagents to detect H7N9 (A/Anhui/1/2013) HA and H7N9 (A/Shanghai/1/2013) HA in WB. Using a DAB detection system, the detection limit for both H7N9 (A/Anhui/1/2013) HA and H7N9 (A/Shanghai/1/2013) HA are approximately 100 ng/lane under reducing conditions.
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Hemagglutinin / HA Background Information

The influenza viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of host endosomal membrane with the viral membrane.The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
Full Name
Harvey rat sarcoma viral oncogene homolog
  • White JM, Hoffman LR, Arevalo JH, et al. (1997). ""Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin"". In Chiu W, Burnett RM, Garcea RL. Structural Biology of Viruses.
  • Suzuki Y (March 2005). ""Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses"". Biol. Pharm. Bull. 28 (3): 399–408.
  • Senne DA, Panigrahy B, Kawaoka Y, et al. (1996). ""Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential"". Avian Dis. 40 (2): 425–37
  • Hemagglutinin stalk domain from H5N1 strain as a potentially universal antigen.
    K Uranowska, J Tyborowska, A Jurek…
    Acta biochimica polonica
  • Protective immunity to H7N9 influenza viruses elicited by synthetic DNA vaccine
    Yan, J;Villarreal, DO;Racine, T;Chu, JS;Walters, JN;Morrow, MP;Khan, AS;Sardesai, NY;Kim, JJ;Kobinger, GP;Weiner, DB;
    Indirect immunofluorescent assay
  • Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses.
    Bahl, K;Senn, JJ;Yuzhakov, O;Bulychev, A;Brito, LA;Hassett, KJ;Laska, ME;Smith, M;Almarsson, 脰;Thompson, J;Ribeiro, AM;Watson, M;Zaks, T;Ciaramella, G;
    Mol. Ther.

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