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Angiopoietin-2/ANG2  蛋白

All ANG2 Reagents

表達宿主: Human Cells  
  • Slide 1
10691-H07H-100
10691-H07H-5
10691-H07H-20
100 µg 
5 µg 
20 µg 
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描述: Active  
表達宿主: Human Cells  
  • Slide 1
10691-H02H-20
10691-H02H-50
20 µg 
50 µg 
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描述: Active  
表達宿主: Human Cells  
  • Slide 1
10691-H08H-20
10691-H08H-50
10691-H08H-5
20 µg 
50 µg 
5 µg 
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表達宿主: Human Cells  
  • Slide 1
  • Slide 1
50298-M07H-20
50298-M07H-50
20 µg 
50 µg 
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表達宿主: Human Cells  
  • Slide 1
90026-C07H-5
90026-C07H-20
90026-C07H-100
5 µg 
20 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
90026-C01H-5
90026-C01H-20
90026-C01H-100
5 µg 
20 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
70034-D07H-10
70034-D07H-50
70034-D07H-200
10 µg 
50 µg 
200 µg 
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Angiopoietin-2/ANG2 相關信號通路

Angiopoietin-2/ANG2 相關蛋白、抗體、cDNA基因、ELISA試劑盒

Angiopoietin-2/ANG2 概述&蛋白信息

Angiopoietin-2/ANG2 研究背景

亞單位結構: Interacts with TEK/TIE2, competing for the same binding site as ANGPT1.
結構域: The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.
亞細胞定位: Secreted.
相似的序列: Contains 1 fibrinogen C-terminal domain.
General information above from UniProt

Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine kinase receptor, Tie-2, found primarily on the luminal surface of endothelial cells. ANG-2's role in angiogenesis generally is considered as an antagonist for ANG1, inhibiting ANG1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. ANG-2 modulates angiogenesis in a cooperative manner with another important angiogenic factor, vascular endothelial growth factor A. Genetic studies have revealed that ANG-2 also is critical in lymphangiogenesis during development. ANG-2 has multiple physiologic effects that regulate vascular tone, hormone secretion, tissue growth and neural activity. Several reports indicate that ANG-2 can induce neovascularization in experimental systems due to the expression of different growth factors such as angiopoietin 2, vascular endothelial factor, and its receptor, fibroblast growth factor, platelet derived growth factor, transforming growth factor beta and epidermal growth factor. In addition, ANG-2 is strongly expressed in the vasculature of many tumors and it has been suggested that ANG-2 may act synergistically with other cytokines such as vascular endothelial growth factor to promote tumor-associated Angiogenesis and tumor progression.

Angiopoietin-2/ANG2 別稱

Angiopoietin-2/ANG2 相關文獻

  • Thomas M, et al. (2009) The role of the Angiopoietins in vascular morphogenesis. Angiogenesis. 12(2): 125-37.
  • Hu B, et al. (2009) Angiopoietin-2: development of inhibitors for cancer therapy. Curr Oncol Rep. 11(2): 111-6.
  • Fiedler U, et al. (2006) Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol. 27: 552-8.
  • Escobar E, et al. (2004) Angiotensin II, cell proliferation and angiogenesis regulator: biologic and therapeutic implications in cancer. Curr Vasc Pharmacol. 2(4): 385-99.
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