alanyl-tRNA synthetase: alanyl-tRNA synthetase Protein | alanyl-tRNA synthetase Antibody

alanyl-tRNA synthetase Gene family

alanyl-tRNA synthetase Background

Alanyl-tRNA synthetase (AARS) belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. This enzyme participates in alanine and aspartate metabolism and aminoacyl-tRNA biosynthesis. Alanyl-tRNA synthetase (AlaRS) catalyzes synthesis of Ala-tRNA (Ala) and hydrolysis of mis-acylated Ser- and Gly-tRNA (Ala) at 2 different catalytic sites. Their role is not confined to catalyze the attachment of amino acids to transfer RNAs and thereby establish the rules of genetic code by virtue of matching the nucleotide triplet of anticodon with cognate amino acid. Under apoptotic conditions in cell culture, the full-length enzyme is secreted, and the two cytokine activities can be generated by leukocyte elastase, an extracellular protease. Secretion of this tRNA synthetase may contribute to apoptosis both by arresting translation and producing needed cytokines. This protein could be an attractive target of drugs against bacterial, fungal and parasitic infections.

Reference for alanyl-tRNA synthetase

  • Wakasugi K, et al. (1999) Two Distinct Cytokines Released from a Human Aminoacyl-tRNA Synthetase. Science. 284 (5411): 147-51.
  • Sokabe M, et al. (2009) The structure of alanyl-tRNA synthetase with editing domain. Proc Natl Acad Sci . 106 (27): 11028-33.
  • Skupinska M, et al. (2009) AARS--the etiological factor and the attractive target of many disorders. Postepy Biochem. 55 (4): 373-84.

alanyl-tRNA synthetase Protein

alanyl-tRNA synthetase protein function

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438). {ECO:0000255|HAMAP-Rule:MF_03133, ECO:0000269|PubMed:27622773, ECO:0000269|PubMed:27911835, ECO:0000269|PubMed:28493438}.

alanyl-tRNA synthetase protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    968.00
  • Mass (Da)
    106.00

alanyl-tRNA synthetase Antibody

There are 2 alanyl-tRNA synthetase antibodies which are validated in multiple tissues with various applications, including WB, IP, ELISA, IHC-P, ICC/IF. There are 2 alanyl-tRNA synthetase antibody for WB, 2 alanyl-tRNA synthetase antibody for IP, 1 alanyl-tRNA synthetase antibody for ELISA, 1 alanyl-tRNA synthetase antibody for IHC-P, 1 alanyl-tRNA synthetase antibody for ICC/IF. Among all these alanyl-tRNA synthetase antibodies, there are 2 anti-alanyl-tRNA synthetase rabbit polyclonal antibodies . All the alanyl-tRNA synthetase anbodies are produced in house and all are in stock. alanyl-tRNA synthetase antibody customerized service is available.

alanyl-tRNA synthetase Gene

AARS cDNA / gene is a protein coding gene.The AARS gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.235 organisms have orthologs with human gene AARS