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ASGR2 / ASGPR2  Protein, Antibody, ELISA Kit, cDNA Clone

描述:   
表達宿主: Human Cells  
13908-H07H-50
13908-H07H-20
50 µg 
20 µg 
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ASGR2 / ASGPR2 相关研究领域

ASGR2 / ASGPR2 相關信號通路

    ASGR2 / ASGPR2 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    ASGR2 / ASGPR2 概述&蛋白信息

    ASGR2 / ASGPR2 研究背景

    基因概述: This ASGR2 gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. ASGR2 is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
    General information above from NCBI
    亞單位結構: The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2. {ECO:0000269|PubMed:11543633}.
    亞細胞定位: Membrane; Single-pass type II membrane protein.
    組織特異性: Expressed exclusively in hepatic parenchymal cells.
    相似的序列: Contains 1 C-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00040}.
    General information above from UniProt

    ASGR2 is a subunit of the asialoglycoprotein receptor. Asialoglycoprotein receptor, also known as the Ashwell receptor, which is specific for desialylated (galactosyl-terminal) glycoproteins and is expressed exclusively in hepatic parenchymal cells. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. ASGR2 is a glycoprotein. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. ASGR2 is the less abundant minor subunit.

    ASGR2 / ASGPR2 別稱

    HL-2,HBXBP,ASGPR2,ASGP-R2,CLEC4H2, [homo-sapiens]
    ASGPR2,ASGP-R2,CLEC4H2,FLJ60040,HBXBP,HL-2, [human]
    ASGPR2,Asgr,Asgr-2,DN-490M13.1, [mouse]
    Asgr,ASGPR2,Asgr-2, [mus-musculus]

    ASGR2 / ASGPR2 相關文獻

  • Davila S, et al. (2010) New genetic associations detected in a host response study to hepatitis B vaccine. Genes Immun. 11(3):232-8.
  • Zhang X, et al. (2011) Asialoglycoprotein receptor interacts with the preS1 domain of hepatitis B virus in vivo and in vitro. Arch Virol. 156(4):637-45.
  • Guy CS, et al. (2011) Hepatocyte cytotoxicity is facilitated by asialoglycoprotein receptor. Hepatology. 54(3):1043-50.
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