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ASGPR1   Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
  • Slide 1
10773-H07H-50
10773-H07H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
50083-M07H-100
50083-M07H-50
100 µg 
50 µg 
Add to Cart

ASGPR1  相關信號通路

    ASGPR1  相關蛋白、抗體、cDNA基因、ELISA試劑盒

    ASGPR1  相關蛋白、抗體、cDNA基因、ELISA試劑盒

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    ASGPR1  概述&蛋白信息

    ASGPR1  研究背景

    基因概述: This ASGPR1 gene encodes a subunit of the asialoglycoprotein receptor. ASGPR1 is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. ASGPR1 may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this ASGPR1 gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
    General information above from NCBI
    亞單位結構: Interacts with LASS2.
    亞細胞定位: Isoform H1a: Membrane; Single-pass type II membrane protein.
    Isoform H1b: Secreted.
    組織特異性: Expressed exclusively in hepatic parenchymal cells.
    翻譯後修飾: Phosphorylated on a cytoplasmic Ser residue.
    相似的序列: Contains 1 C-type lectin domain.
    General information above from UniProt

    The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.

    ASGPR1  別稱

    ASGPR1  相關文獻

  • Yang J, et al. (2006) Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. J Viral Hepat. 13(3): 158-65.
  • Li Y, et al. (2008) Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. Curr Drug Deliv. 5(4): 299-302.
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