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ANTXR2 / CMG2  蛋白

All ANTXR2  Reagents

表達宿主: Human Cells  
15762-H02H-50
15762-H02H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
51131-M02H-50
51131-M02H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
51131-M08H-50
51131-M08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

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ANTXR2 / CMG2 相关研究领域

ANTXR2 / CMG2 相關信號通路

    ANTXR2 / CMG2 概述&蛋白信息

    ANTXR2 / CMG2 研究背景

    亞單位結構: Binds laminin, and possibly also collagen type IV. Binds to the protective antigen (PA) of Bacillus anthracis in a divalent cation-dependent manner, with the following preference: calcium > manganese > magnesium > zinc. Binding of PA leads to heptamerization of the receptor-PA complex.
    結構域: Binding to PA seems to be effected through the VWA domain.
    亞細胞定位: Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Expressed at the cell surface.; Isoform 2: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.; Isoform 3: Secreted.
    組織特異性: Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen. {ECO:0000269|PubMed:14508707}.
    相關疾病 : DISEASE: Hyaline fibromatosis syndrome (HFS) [MIM:228600]: An autosomal recessive syndrome characterized by abnormal growth of hyalinized fibrous tissue usually affecting subcutaneous regions on the scalp, ears, neck, face, hands, and feet. The lesions appear as pearly papules or fleshy nodules. Additional features include gingival hypertrophy, progressive joint contractures resulting in severe limitation of mobility, osteopenia, and osteoporosis. Disease severity is variable. Some individuals manifest symptoms in infancy and have additional visceral or systemic involvement. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to early death. Surviving children may suffer from severely reduced mobility due to joint contractures. Other patients have later onset of a milder disorder affecting only the face and digits. {ECO:0000269|PubMed:12973667, ECO:0000269|PubMed:14508707, ECO:0000269|PubMed:15725249}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    相似的序列: Belongs to the ATR family. {ECO:0000305}.; Contains 1 VWFA domain. {ECO:0000255|PROSITE-ProRule:PRU00219}.
    General information above from UniProt

    ANTXR2 / CMG2 別稱

    HFS,ISH,JHF,CMG2,CMG-2, [homo-sapiens]
    anthrax toxin receptor 2,ANTXR2,CMG-2,CMG2,HFS,ISH,JHF,capillary morphogenesis gene 2 protein,capillary morphogenesis protein 2, [human]
    anthrax toxin receptor 2,Antxr2,2310046B19Rik,AW561899,CMG-2,CMG2,cI-35, [mouse]
    CMG2,CMG-2,cI-35,AW561899,2310046B19Rik, [mus-musculus]

    ANTXR2 / CMG2 相關文獻

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