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ALK-4 / ACVR1B  蛋白

All ALK-4 Reagents

描述: Active  
表達宿主: Human Cells  
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10583-H08H-100
10583-H08H-200
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描述: Active  
表達宿主: Human Cells  
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10583-H03H-100
10583-H03H-200
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表達宿主: Human Cells  
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51132-M02H-50
51132-M02H-100
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表達宿主: Human Cells  
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80137-R02H-50
80137-R02H-100
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表達宿主: Human Cells  
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90066-C02H-50
90066-C02H-100
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ALK-4 / ACVR1B 相關信號通路

ALK-4 / ACVR1B 概述&蛋白信息

ALK-4 / ACVR1B 研究背景

基因概述: ACVR1B gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This ALK4 protein is a type I receptor which is essential for signaling. Mutations in ACVR1B gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
General information above from NCBI
催化活性: ATP + [receptor-protein] = ADP + [receptor- protein] phosphate.
輔因數: Magnesium or manganese (By similarity).
酶調控: Activin receptor type-2 (ACVR2A or ACVR2B) activates the type-1 receptor through phosphorylation of its regulatory GS domain.
亞單位結構: Forms an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Interacts with TDP2 (By similarity). Interacts with AIP1, FKBP1A, IGSF1, TDGF1, SMAD2, SMAD3 and SMAD7.
結構域: The GS domain is a 30-amino-acid sequence adjacent to the N-terminal boundary of the kinase domain and highly conserved in all other known type-1 receptors but not in type-2 receptors. The GS domain is the site of activation through phosphorylation by the II receptors.
亞細胞定位: Cell membrane; Single-pass type I membrane protein (By similarity).
組織特異性: Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
翻譯後修飾: Autophosphorylated. Phosphorylated by activin receptor type-2 (ACVR2A or ACVR2B) in response to activin-binding at serine and threonine residues in the GS domain. Phosphorylation of ACVR1B by activin receptor type-2 regulates association with SMAD7.
Ubiquitinated. Level of ubiquitination is regulated by the SMAD7-SMURF1 complex.
相關疾病 : Note=ACVRIB is abundantly expressed in systemic sclerosis patient fibroblasts and production of collagen is also induced by activin-A/INHBA. This suggests that the activin/ACRV1B signaling mechanism is involved in systemic sclerosis.
相似的序列: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.C
General information above from UniProt

ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.

ALK-4 / ACVR1B 別稱

ALK-4 / ACVR1B 相關文獻

  • Chen Y, et al. (2005) Developmental analysis of activin-like kinase receptor-4 (ALK4) expression in Xenopus laevis. 232(2): 393-8.
  • J. Massagu. (1998) TGF- SIGNAL TRANSDUCTION. Annual Review of Biochemistry. 67: 753-91.
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