All ALK4/ACVR1B reagents are produced in house and quality controlled, including 2 ALK4/ACVR1B Antibody, 52 ALK4/ACVR1B Gene, 5 ALK4/ACVR1B Lysate, 5 ALK4/ACVR1B Protein, 2 ALK4/ACVR1B qPCR. All ALK4/ACVR1B reagents are ready to use.
Recombinant ALK4/ACVR1B proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-human IgG1-Fc & His, C-His.
ALK4/ACVR1Bantibodies are validated with different applications, which are WB, ELISA.
ALK4/ACVR1BcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each ALK4/ACVR1B of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.