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食蟹猴 ALK-2 / ACVR1 / ALK2 蛋白 (Fc 標籤)

  • Cynomolgus ALK-2 / ACVR1 / ALK2 Protein (Fc Tag) SDS-PAGE
產品資料評論相關產品實驗方法
食蟹猴 ALK-2/ACVR1 蛋白產品資訊
分子別稱:ACVR1
蛋白構建:A DNA sequence encoding the cynomolgus ACVR1 (F7A9J8) (Met1-Glu123) was expressed with the Fc region of human IgG1 at the C-terminus.
分子種屬:Cynomolgus
表達宿主:Human Cells
#N/A:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
食蟹猴 ALK-2/ACVR1 蛋白質控檢測
純度:(75.3+22.3) % as determined by SDS-PAGE
內毒素:< 1.0 EU per μg of the protein as determined by the LAL method
穩定性:Samples are stable for up to twelve months from date of receipt at -70℃
預測N端:Asp 23
分子量:The recombinant cynomolgus ACVR1 is a disulfide-linked homodimer. The reduced monomer comprises 342 amino acids and has a calculated molecular mass of 38.2 KDa.The apparent molecular mass of the protein is approximately 44 and 37 KDa respectively in SDS-PAGE.
緩衝液:Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
食蟹猴 ALK-2/ACVR1 蛋白使用指導
儲存方法:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
#N/A:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
食蟹猴 ALK-2/ACVR1 Protein SDS-PAGE
Cynomolgus ALK-2 / ACVR1 / ALK2 Protein (Fc Tag) SDS-PAGE

ALK-2/ACVR1 相關信號通路

Other ALK-2/ACVR1 Recombinant Protein Products
90058-C02H
ALK-2/ACVR1 研究背景

ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been demonstrated that ALK-2 forms complex with either the BMP-2/7-bound BMPR-II or ACVR2A /ACVR2B. ALK-1 and ALK-2 presenting in the yeast Saccharomyces cerevisiae are two haspin homologues. Both ALK-1 and ALK-2 exhibit a weak auto-kinase activity in vitro, and are phosphoproteins in vivo. ALK-1 and ALK-2 levels peak in mitosis and late-S/G2. Control of protein stability plays a major role in ALK-2 regulation. The half-life of ALK-2 is particularly short in G1. Overexpression of ALK-2, but not of ALK-1, causes a mitotic arrest, which is correlated to the kinase activity of the protein. This suggests a role for ALK-2 in the control of mitosis. Endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK-2 and ALK-5 in prostate cancer cells. Endoglin did not inhibit cell migration in the presence of constitutively active ALK-2. Defects in ALK-2 are a cause of fibrodysplasia ossificans progressiva (FOP).

食蟹猴 ALK-2/ACVR1 參考資料
  • Armes NA,et al. (1997) The ALK-2 and ALK-4 activin receptors transduce distinct mesoderm-inducing signals during early Xenopus development but do not co-operate to establish thresholds. Development 124(19): 3797-804.
  • Armes NA, et al. (1999) A short loop on the ALK-2 and ALK-4 activin receptors regulates signaling specificity but cannot account for all their effects on early Xenopus development. J Biol Chem. 274(12):7929-35.
  • Kawai S, et al. (2000) Mouse smad8 phosphorylation downstream of BMP receptors ALK-2, ALK-3, and ALK-6 induces its association with Smad4 and transcriptional activity.Biochem Biophys Res Commun. 271(3):682-7.
  • Deng Y, et al. (2009) Efficient highly selective synthesis of methyl 2-(ethynyl)alk-2(E)-enoates and 2-(1'-chlorovinyl)alk-2(Z)-enoates from 2-(methoxycarbonyl)-2,3-allenols. Organic letters 11(10):2169-72.
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    貨號: 90058-C02H-100
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