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AK4 / Adenylate Kinase 4 / AK3L1  蛋白

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表達宿主: Baculovirus-Insect Cells  
12406-HNCB-50
50 µg 
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表達宿主: Baculovirus-Insect Cells  
12406-H20B-50
50 µg 
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AK4 / Adenylate Kinase 4 / AK3L1 相关研究领域

AK4 / Adenylate Kinase 4 / AK3L1 相關信號通路

    AK4 / Adenylate Kinase 4 / AK3L1 概述&蛋白信息

    AK4 / Adenylate Kinase 4 / AK3L1 研究背景

    基因概述: This AK3L1 gene encodes a member of the adenylate kinase family of enzymes. AK3L1 is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this AK3L1 gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    催化活性: NTP + AMP = NDP + ADP. {ECO:0000255|HAMAP-Rule:MF_03170}.; ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. {ECO:0000255|HAMAP-Rule:MF_03170}.
    亞單位結構: Monomer. {ECO:0000255|HAMAP-Rule:MF_03170, ECO:0000269|Ref.12}.
    結構域: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
    亞細胞定位: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03170, ECO:0000269|PubMed:11485571, ECO:0000269|PubMed:19766732}.
    組織特異性: Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain. {ECO:0000269|PubMed:11485571}.
    相似的序列: Belongs to the adenylate kinase family. AK3 subfamily. {ECO:0000255|HAMAP-Rule:MF_03170}.
    General information above from UniProt

    Adenylate kinase isoenzyme 4, mitochondrial, also known as ATP-AMP transphosphorylase, Adenylate kinase 3-like, AK4 and AK3L1, is a member the adenylate kinase family. AK4 / AK3L1 is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. AK4 / AK3L1 catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. It may also be active with GTP. Adenylate kinase 4 ( AK4 / AK3L1 ) is a unique member with no enzymatic activity in the adenylate kinase (AK) family although it shares high sequence homology with other AKs. It remains unclear what physiological function AK4 might play or why it is enzymatically inactive. AK4 / AK3L1 retains the capability of binding nucleotides. It has a glutamine residue instead of a key arginine residue in the active site well conserved in other AKs. The enzymatically inactive AK4 is a stress responsive protein critical to cell survival and proliferation. AK4 / AK3L1 is likely that the interaction with the mitochondrial inner membrane protein ANT is important for AK4 to exert the protective benefits to cells under stress. AK4 / AK3L1 also acts on the specific mechanism of energy metabolism rather than control of the homeostasis of the ADP pool ubiquitously.

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