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AK2 / Adenylate kinase 2 抗體, 兔單抗

  • AK2 / Adenylate kinase 2 Antibody, Rabbit MAb
  • AK2 / Adenylate kinase 2 Antibody, Rabbit MAb, Immunohistochemistry
  • AK2 / Adenylate kinase 2 Antibody, Rabbit MAb, Immunohistochemistry
產品資料評論相關產品實驗方法
 AK2 抗體產品資訊
免疫原:Recombinant Human AK2 protein (Catalog#13146-H20B)
Clone ID:025
Ig類型:Rabbit IgG
濃度:
內毒素:
緩衝液:0.2 μm filtered solution in PBS with 5% trehalose
抗體製備方法:This antibody was obtained from a rabbit immunized with purified, recombinant Human AK2 (rh AK2; Catalog#13146-H20B; P54819-1; Met1-Ile239).
 AK2 Antibody WB Application Image
 AK2 Antibody IHC Application Image
AK2 / Adenylate kinase 2 Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of human AK2 in human kidney with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
AK2 / Adenylate kinase 2 Antibody, Rabbit MAb, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human AK2 in human liver with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Other AK2 Antibody Products
AK2 / Adenylate kinase 2 研究背景

Adenylate kinase 2 (AK2) belongs to the Adenylate kinase family that contains three isozymes: AK1, AK2 and AK3. Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Adenylate kinase2 (AK2) is expressed in mitochondrial intermembrane space. It may play a role in apoptosis. It has been demonstrated that in apoptotic cells AK2 was translocated into the cytosol concomitantly with cytochronme C. Mutations in this gene are the cause of reticular dysgenesis. These mutations result in absent or strongly decreased protein expression. It has been also established that AK2 is specifically expressed in the stria vascularis region of the inner ear, which provides an explanation of the sensorineural deafness in these individuals. 

 AK2 / Adenylate kinase 2 參考資料
  • Lagresle-Peyrou C, et al. (2008) Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nature Genetics. 41: 106-11.
  • Bruns GA, et al. (1977) Adenylate kinase 2, a mitochondrial enzyme. Biochem Genet. 15 (5-6): 477-86.
  • Khler C, et al. (1999) Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis. FEBS Lett. 447 (1): 10-2.
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    貨號: 13146-R025-50
    目錄價: 
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    Datasheet & Documentation

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