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Alpha-fetoprotein/AFP  Protein, Antibody, ELISA Kit, cDNA Clone

Alpha-fetoprotein/AFP 相关研究领域

Alpha-fetoprotein/AFP 相關信號通路

    Alpha-fetoprotein/AFP 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    Alpha-fetoprotein/AFP 概述&蛋白信息

    Alpha-fetoprotein/AFP 研究背景

    基因概述: This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly
    General information above from NCBI
    亞單位結構: Dimeric and trimeric forms have been found in addition to the monomeric form.
    亞細胞定位: Secreted.
    組織特異性: Plasma. Synthesized by the fetal liver and yolk sac.
    發育階段: Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.
    翻譯後修飾: Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.; Sulfated. {ECO:0000269|PubMed:2414772}.
    相關疾病 : DISEASE: Alpha-fetoprotein deficiency (AFPD) [MIM:615969]: A benign condition characterized by undetectable AFP levels in the amniotic fluid. Affected individuals are asymptomatic and present normal development. {ECO:0000269|PubMed:15280901, ECO:0000269|PubMed:18854864}. Note=The disease is caused by mutations affecting the gene represented in this entry.; DISEASE: Alpha-fetoprotein, hereditary persistence (HPAFP) [MIM:615970]: A benign autosomal dominant condition characterized by continued expression of alpha-fetoprotein in adult life. {ECO:0000269|PubMed:7684942}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    相似的序列: Belongs to the ALB/AFP/VDB family. {ECO:0000255|PROSITE-ProRule:PRU00769}.; Contains 3 albumin domains. {ECO:0000255|PROSITE-ProRule:PRU00769}.
    General information above from UniProt

    Alpha-fetoprotein (AFP) is classified as a member of the albuminoid gene superfamily consisting of albumin, AFP, vitamin D (Gc) protein, and alpha-albumin. AFP is a glycoprotein of 591 amino acids and a carbohydrate moiety. AFP is one of the several embryo-specific proteins and is a dominant serum protein as early in human embryonic life as one month, when albumin and transferrin are present in relatively small amounts. It is first synthesized in the human by the yolk sac and liver(1-2 months) and subsequently predominantly in the liver. A small amount of AFP is produced by the GI tract of the human conceptus. It has been proved that AFP may reappear in the serum in elevated amounts in adult life in association with normal restorative processes and with malignant growth. Alpha-fetoprotein (AFP) is a specific marker for hepatocellular carcinoma (HCC), teratoblastomas, and neural tube defect (NTD).

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    Alpha-fetoprotein/AFP 別稱

    Alpha-fetoprotein,AFPD, []
    AFPD,FETA,HPAFP, [homo-sapiens]
    FETA,HPAFP, [human]
    alpha-1-fetoprotein,alpha-fetoprotein,alpha-foetoprotein,alpha-fetoglobulin, [mouse]

    Alpha-fetoprotein/AFP 相關文獻

  • Mizejewski GJ. (2001) Alpha-fetoprotein Structure and Function: Relevance to Isoforms, Epitopes, and Conformational Variants. Exp Biol Med. 226(5): 377-408.
  • Tomasi TB, et al. (1977) Structure and Function of Alpha-Fetoprotein. Annual Review of Medicine. 28: 453-65.
  • Leguy MC, et al. (2011) Assessment of AFP in amniotic fluid: comparison of three automated techniques. Ann Biol Clin. 69(4): 441-6.
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