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Adenosine Receptor A2a  Protein, Antibody, ELISA Kit, cDNA Clone

Adenosine Receptor A2a 相关研究领域

Adenosine Receptor A2a 相關信號通路

    Adenosine Receptor A2a 概述&蛋白信息

    Adenosine Receptor A2a 研究背景

    亞單位結構: Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4. {ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:18832607}.
    結構域: The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.
    亞細胞定位: Cell membrane; Multi-pass membrane protein.
    翻譯後修飾: Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface. {ECO:0000269|PubMed:16339847}.
    相似的序列: Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
    General information above from UniProt

    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.

    Immune Checkpoint
    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    Adenosine Receptor A2a 別稱

    A2aR,RDC8,ADORA2, [homo-sapiens]
    A2aR,A2AAR,AA2AR, [mus-musculus]

    Adenosine Receptor A2a 相關文獻

  • Alchera E, Imarisio C, Mandili G, et al. Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype. BioMed Research International. 2015;2015:286746.
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