Text Size:AAA

ACE2 / Angiotensin-Converting Enzyme 2  Protein, Antibody, ELISA Kit, cDNA Clone

描述: Active  
表達宿主: Human Cells  
10108-H02H-20
10108-H02H-10
20 µg 
10 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
10108-H05H-50
10108-H05H-10
50 µg 
10 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
50249-M03H-20
50249-M03H-10
20 µg 
10 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
50249-M08H-20
50249-M08H-10
20 µg 
10 µg 
Add to Cart
  • Slide 1
描述: Active  
表達宿主: Human Cells  
80031-R08H-20
80031-R08H-10
20 µg 
10 µg 
Add to Cart
  • Slide 1
描述: Active  
表達宿主: Human Cells  
90211-C08H-20
90211-C08H-10
20 µg 
10 µg 
Add to Cart
  • Slide 1
描述: Active  
表達宿主: Human Cells  
90211-C02H-20
90211-C02H-10
20 µg 
10 µg 
Add to Cart
  • Slide 1

ACE2 / Angiotensin-Converting Enzyme 2 相关研究领域

ACE2 / Angiotensin-Converting Enzyme 2 相關信號通路

    ACE2 / Angiotensin-Converting Enzyme 2 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    ACE2 / Angiotensin-Converting Enzyme 2 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    Featured Reagent Products

    ACE2 / Angiotensin-Converting Enzyme 2 概述&蛋白信息

    ACE2 / Angiotensin-Converting Enzyme 2 研究背景

    基因概述: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
    General information above from NCBI
    催化活性: Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine.
    輔因數: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:11815627}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:11815627};; Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence={ECO:0000269|PubMed:11815627}; ; Note=Binds 1 Cl(-) ion per subunit. {ECO:0000269|PubMed:11815627};
    酶調控: ENZYME REGULATION: Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:11815627, ECO:0000269|PubMed:15231706}.
    亞單位結構: Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike glycoprotein. Interacts with the catalytically active form of TMPRSS2. {ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15276642, ECO:0000269|PubMed:15452268, ECO:0000269|PubMed:15791205, ECO:0000269|PubMed:15897467, ECO:0000269|PubMed:21068237}.
    亞細胞定位: Processed angiotensin-converting enzyme 2: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm {ECO:0000250}. Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250}.
    組織特異性: Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system. {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:12459472, ECO:0000269|PubMed:15141377, ECO:0000269|PubMed:15231706, ECO:0000269|PubMed:15671045}.
    誘導: Up-regulated in failing heart. {ECO:0000269|PubMed:15151696, ECO:0000269|PubMed:15671045}.
    翻譯後修飾: N-glycosylation on Asn-90 may limit SARS infectivity. {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19159218}.; Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1. {ECO:0000269|PubMed:15983030, ECO:0000269|PubMed:21068237, ECO:0000269|PubMed:21563828, ECO:0000269|PubMed:24227843}.
    相似的序列: Belongs to the peptidase M2 family. {ECO:0000305}.
    General information above from UniProt

    Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme, an homolog of ACE, hydrolyzes angiotensin (Ang) I to produce Ang-(1-9), which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus, the major biologically active product of ACE2 is Ang-(1-7), which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis.

    ACE2 / Angiotensin-Converting Enzyme 2 別稱

    ACEH, [homo-sapiens]
    ACE2,ACEH,DKFZp434A014, [human]
    2010305L05Rik,Ace2,RP23-330O24.1, [mouse]
    2010305L05Rik, [mus-musculus]

    ACE2 / Angiotensin-Converting Enzyme 2 相關文獻

  • Koitka A, et al. (2008) Angiotensin converting enzyme 2 in the kidney. Clin Exp Pharmacol Physiol. 35(4): 420-5.
  • Raizada MK, et al. (2007) ACE2: a new target for cardiovascular disease therapeutics. J Cardiovasc Pharmacol. 50(2): 112-9.
  • Imai Y, et al. (2007) Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 74(3): 405-10.
  • Turner AJ, et al. (2004) ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci. 25(6): 291-4.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”