ABP1 / AOC1: ABP1 / AOC1 Protein | ABP1 / AOC1 Antibody

ABP1 / AOC1 Background

Amine oxidase copper-containing 1 (AOC1; formerly known as amiloride-binding protein 1) is a secreted glycoprotein that catalyzes the degradation of putrescine and histamine. Polyamines and their diamine precursor putrescine are ubiquitous to all organisms and fulfill pivotal functions in cell growth and proliferation. That the Wilms tumor protein, WT1, which is necessary for normal kidney development, activates transcription of the AOC1 gene. Expression of a firefly luciferase reporter under control of the proximal AOC1 promoter was significantly enhanced by co-transfection of a WT1 expression construct. Binding of WT1 protein to a cis-regulatory element in the AOC1 promoter was confirmed by electrophoretic mobility shift assay and chromatin immunoprecipitation. WT1-dependent control of polyamine breakdown, which is mediated by changes in AOC1 expression, has a role in kidney organogenesis.

Reference for ABP1 / AOC1

  • Kirschner KM, et al. (2014) Amine oxidase copper-containing 1 (aoc1) is a downstream target gene of the wilms tumor protein, wt1, during kidney development. J Biol Chem 289(35), 24452-24462.
  • Neumann P, et al. (2012) Crystal structures of physcomitrella patens aoc1 and aoc2: Insights into the enzyme mechanism and differences in substrate specificity. Plant Physiol 160(3), 1251-1266.

ABP1 / AOC1 Protein

ABP1 / AOC1 protein function

Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.

ABP1 / AOC1 protein expression

Tissue specificity

Placenta and kidney.

ABP1 / AOC1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    751.00
  • Mass (Da)
    85.00

ABP1 / AOC1 Antibody

There are 4 ABP1 / AOC1 antibodies which are validated in multiple tissues with various applications, including ELISA. There are 4 ABP1 / AOC1 antibody for ELISA. Among all these ABP1 / AOC1 antibodies, there are 1 anti-ABP1 / AOC1 mouse monoclonal antibodies , 1 anti-ABP1 / AOC1 rabbit monoclonal antibodies , 2 anti-ABP1 / AOC1 rabbit polyclonal antibodies . All the ABP1 / AOC1 anbodies are produced in house and all are in stock. ABP1 / AOC1 antibody customerized service is available.

ABP1 / AOC1 Gene

AOC1 gene / cDNA is a protein-coding gene which located on 7q36.1. The AOC1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.176 organisms have orthologs with human gene AOC1.